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403337 occurrences (No.43 in the rank) during 5 years in the PubMed. [cache]
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403337 occurrences (No.43 in the rank) during 5 years in the PubMed. [cache]
| 147) In this research, ∊2, ∊3, and ∊4 polymorphisms of ApoE gene and C889T polymorphism of IL-1α gene were genotyped in patients with AD and controls. |
| PMID:23038715 DOI:10.1177/1533317512461557 |
| 2015 American journal of Alzheimer's disease and other dementias |
| * Association of Alzheimer's Disease With APOE and IL-1α Gene Polymorphisms. |
| - Apolipoprotein E (ApoE) gene polymorphisms are thought to be the most important genetic risk factor in the pathogenesis of late onset and sporadic Alzheimer's disease (AD). Moreover, interleukin-1α (IL-1α) is found to be associated with the pathogenesis of AD. In this research, ∊2, ∊3, and ∊4 polymorphisms of ApoE gene and C889T polymorphism of IL-1α gene were genotyped in patients with AD and controls. Genotyping was performed by real-time polymerase chain reaction. ∊3/∊3 and ∊3/∊4 genotype frequencies were significantly higher in control and case groups, respectively. While ∊3 allele frequencies were significantly higher in the control group, ∊2 and ∊4 allele frequencies were significantly higher among the cases with AD. No difference was found between the groups according to C889T polymorphism of IL-1α. In conclusion, we demonstrated that there was a strong association between ApoE ∊4 allele and AD, while there was no relation with IL-1α C889T polymorphisms for this study. |
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(15)5 of |
(29)3 block |
(43)2 mutation |
| (2)34 order |
(16)5 transfer |
(30)3 can |
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| (3)32 arrangement |
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(45)2 overlap |
| (4)31 and |
(18)4 activation |
(32)3 polymorphisms |
(46)2 peptide |
| (5)21 *null* | (19)4 delivery |
(33)3 sequencing |
(47)2 profiling |
| (6)15 was |
(20)4 encoding |
(34)3 transcription |
(48)2 regions |
| (7)12 expression, |
(21)4 expressions |
(35)2 analysis |
(49)2 sequence |
| (8)9 arrangement, |
(22)4 fragments |
(36)2 carriers |
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| (9)7 composition |
(23)4 is |
(37)2 cluster |
(51)2 spookier |
| (10)7 organization |
(24)4 silencing |
(38)2 clusters |
(52)2 synteny |
| (11)7 sequences |
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(39)2 content |
(53)2 therapy, |
| (12)5 flow |
(26)4 which |
(40)2 family |
(54)2 used |
| (13)5 for |
(27)3 alterations |
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| (14)5 in |
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