ELIZA cgi-bash version rev. 1.91
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for gene out of >500 occurrences
403337 occurrences (No.43 in the rank) during 5 years in the PubMed. [cache]
391) We found harsh parenting significantly predicted methylation of several HPA axis genes, including novel gene associations with AVPRB1, CRHR1, CRHR2, and MC2R (FDR corrected p < 0.05).
--- ABSTRACT ---
PMID:32472381 DOI:10.1007/s10571-020-00885-4
2021 Cellular and molecular neurobiology
* Harsh Parenting Predicts Novel HPA Receptor Gene Methylation and NR3C1 Methylation Predicts Cortisol Daily Slope in Middle Childhood.
- Adverse experiences in childhood are associated with altered hypothalamic-pituitary-adrenal (HPA) axis function and negative health outcomes throughout life. It is now commonly accepted that abuse and neglect can alter epigenetic regulation of HPA genes. Accumulated evidence suggests harsh parenting practices such as spanking are also strong predictors of negative health outcomes. We predicted harsh parenting at 2.5 years old would predict HPA gene DNA methylation similarly to abuse and neglect, and cortisol output at 8.5 years old. Saliva samples were collected three times a day across 3 days to estimate cortisol diurnal slopes. Methylation was quantified using the Illumina Infinium MethylationEPIC array BeadChip (850 K) with DNA collected from buccal cells. We used principal components analysis to compute a summary statistic for CpG sites across candidate genes. The first and second components were used as outcome variables in mixed linear regression analyses with harsh parenting as a predictor variable. We found harsh parenting significantly predicted methylation of several HPA axis genes, including novel gene associations with AVPRB1, CRHR1, CRHR2, and MC2R (FDR corrected p < 0.05). Further, we found NR3C1 methylation predicted a steeper diurnal cortisol slope. Our results extend the current literature by demonstrating harsh parenting may influence DNA methylation similarly to more extreme early life experiences such as abuse and neglect. Further, we show NR3C1 methylation is associated with diurnal HPA function. Elucidating the molecular consequences of harsh parenting on health can inform best parenting practices and provide potential treatment targets for common complex disorders.
--- ABSTRACT END ---
[
right
kwic]
[frequency of next (right) word to gene]
(1)132 expression (14)5 drive (27)3 duplications (40)2 for
(2)14 *null* (15)5 editing (28)3 ontology (41)2 from
(3)12 expression, (16)5 mutations (29)3 signature (42)2 fusion,
(4)11 and (17)5 of (30)3 to (43)2 have
(5)10 encoding (18)5 regulation (31)3 which (44)2 is
(6)10 set (19)4 networks (32)2 analysis (45)2 ontologies
(7)8 in (20)4 regulatory (33)2 are (46)2 or
(8)8 that (21)4 silencing (34)2 assay, (47)2 pathways
(9)7 1 (22)4 transcription (35)2 called (48)2 profile
(10)6 interaction (23)4 transfer (36)2 cluster (49)2 promoter
(11)6 therapy (24)3 1/itaconate (37)2 delivery (50)2 sequencing
(12)6 was (25)3 co-expression (38)2 detection (51)2 sets
(13)5 Expression (26)3 coexpression (39)2 expressions (52)2 transcripts

add keyword

--- WordNet output for gene --- =>遺伝子 Overview of noun gene The noun gene has 1 sense (no senses from tagged texts) 1. gene, cistron, factor -- ((genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors") --- WordNet end ---