ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for gene out of >500 occurrences
403337 occurrences (No.43 in the rank) during 5 years in the PubMed. [no cache] 500 found
398) Synaptonemal-complex analysis implied that BFA played a positive role in meiosis initiation and this hypothesis was confirmed by quantitative PCR of meiosis-specific genes: stimulated by retinoic acid gene 8 (Stra8) and deleted in a zoospermia-like (DAZL).
--- ABSTRACT ---
PMID:24209976 DOI:10.1071/RD13281
2015 Reproduction, fertility, and development
* Exposure to Brefeldin A promotes initiation of meiosis in murine female germ cells.
- In mammals, ontogenesis starts from a fusion of spermatozoon and oocyte, which are produced by reductive nuclear division of a diploid germ cell in a specialised but complex biological process known as meiosis. However, little is known about the mechanism of meiotic initiation in germ cells, although many factors may be responsible for meiosis both in male and female gonads. In this study, 11.5 days post coitum (dpc) female fetal mouse genital ridges were cultured in vitro with exposure to Brefeldin A (BFA) for 6h, and the changes in meiosis were detected. Synaptonemal-complex analysis implied that BFA played a positive role in meiosis initiation and this hypothesis was confirmed by quantitative PCR of meiosis-specific genes: stimulated by retinoic acid gene 8 (Stra8) and deleted in a zoospermia-like (DAZL). At the same time, mRNA expression of retinoic acid synthetase (Raldh2) and retinoic acid (RA) receptors increased in female gonads with in vitro exposure to BFA. Transplanting genital ridges treated with BFA into the kidney capsule of immunodeficient mice demonstrated that the development capacity of female germ cells was normal, while formation of primordial follicles was seen to be a result of accelerated meiosis after exposure to BFA. In conclusion, the study indicated that BFA stimulated meiosis initiation partly by RA signalling and then promoted the development of follicles.
--- ABSTRACT END ---
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(1)75 expression (15)5 of (29)3 block (43)2 mutation
(2)34 order (16)5 transfer (30)3 can (44)2 on
(3)32 arrangement (17)5 were (31)3 contents (45)2 overlap
(4)31 and (18)4 activation (32)3 polymorphisms (46)2 peptide
(5)21 *null* (19)4 delivery (33)3 sequencing (47)2 profiling
(6)15 was (20)4 encoding (34)3 transcription (48)2 regions
(7)12 expression, (21)4 expressions (35)2 analysis (49)2 sequence
(8)9 arrangement, (22)4 fragments (36)2 carriers (50)2 sequences,
(9)7 composition (23)4 is (37)2 cluster (51)2 spookier
(10)7 organization (24)4 silencing (38)2 clusters (52)2 synteny
(11)7 sequences (25)4 to (39)2 content (53)2 therapy,
(12)5 flow (26)4 which (40)2 family (54)2 used
(13)5 for (27)3 alterations (41)2 from (55)2 uses
(14)5 in (28)3 as (42)2 has

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--- WordNet output for gene --- =>遺伝子 Overview of noun gene The noun gene has 1 sense (no senses from tagged texts) 1. gene, cistron, factor -- ((genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors") --- WordNet end ---