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return kwic search for gene out of >500 occurrences
403337 occurrences (No.43 in the rank) during 5 years in the PubMed. [cache]

402) TGF-β1 enhances the transcription of miR-106b via a promoter independent of its host gene MCM7 by activating c-jun.

--- ABSTRACT ---

PMID:24292682 DOI:10.1038/onc.2013.525

2015 Oncogene

* MiR-106b expression determines the proliferation paradox of TGF-β in breast cancer cells.

- TGF-β has paradoxical effects on cancer cell proliferation, as it suppresses proliferation of normal epithelial and low-invasive cancer cells, but enhances that of high-invasive cancer cells. However, how cancer cells acquire the ability to evade the tumor-suppressing effects of TGF-β, yet still take advantage of its tumor-promoting effects, remains elusive. Here, we identified miR-106b as a molecular switch to determine TGF-β effects on cell proliferation. TGF-β1 enhances the transcription of miR-106b via a promoter independent of its host gene MCM7 by activating c-jun. In high-invasive breast cancer cells, miR-106b is upregulated by TGF-β1 at a much higher level than that in normal or low-invasive cancer cells. Accumulation of miR-106b counterbalances TGF-β growth-inhibiting effects by eliminating activated retinoblastoma (RB) and results in enhanced proliferation. Furthermore, miR-106b mediates TGF-β effects on tumor growth and metastasis in breast cancer xenografts. In addition, miR-106b expression is elevated in higher stage tumors and correlated with tumor progression in breast cancer patients. These findings suggest that high level of miR-106b induced by TGF-β determines the tumor-promoting effects of TGF-β in breast cancer.

--- ABSTRACT END ---

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(1)75 expression	(15)5 of	(29)3 block	(43)2 mutation
(2)34 order	(16)5 transfer	(30)3 can	(44)2 on
(3)32 arrangement	(17)5 were	(31)3 contents	(45)2 overlap
(4)31 and	(18)4 activation	(32)3 polymorphisms	(46)2 peptide
(5)21 null	(19)4 delivery	(33)3 sequencing	(47)2 profiling
(6)15 was	(20)4 encoding	(34)3 transcription	(48)2 regions
(7)12 expression,	(21)4 expressions	(35)2 analysis	(49)2 sequence
(8)9 arrangement,	(22)4 fragments	(36)2 carriers	(50)2 sequences,
(9)7 composition	(23)4 is	(37)2 cluster	(51)2 spookier
(10)7 organization	(24)4 silencing	(38)2 clusters	(52)2 synteny
(11)7 sequences	(25)4 to	(39)2 content	(53)2 therapy,
(12)5 flow	(26)4 which	(40)2 family	(54)2 used
(13)5 for	(27)3 alterations	(41)2 from	(55)2 uses
(14)5 in	(28)3 as	(42)2 has

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--- WordNet output for gene --- =>遺伝子 Overview of noun gene The noun gene has 1 sense (no senses from tagged texts) 1. gene, cistron, factor -- ((genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors") --- WordNet end ---