ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for gene out of >500 occurrences
403337 occurrences (No.43 in the rank) during 5 years in the PubMed. [cache]
404) This 320-gene OCCC signature is enriched in genes associated with stress response and sugar metabolism.
--- ABSTRACT ---
PMID:24105991 DOI:10.1002/mc.22072
2015 Molecular carcinogenesis
* Hepatocyte nuclear factor-1β (HNF-1β) promotes glucose uptake and glycolytic activity in ovarian clear cell carcinoma.
- Ovarian clear cell carcinoma (OCCC) is a morphologically and biologically distinct subtype of ovarian carcinomas that often arises in ovarian endometriosis. We previously reported that a unique carcinogenic environment, especially iron-induced oxidative stress in endometriotic cysts may promote development of OCCC. We also identified a gene expression profile characteristic of OCCC (the "OCCC signature"). This 320-gene OCCC signature is enriched in genes associated with stress response and sugar metabolism. However, the biological implication of this profile is unclear. In this study, we have focused on the biological role of the HNF-1β gene within the OCCC signature, which was previously shown to be overexpressed in OCCC. Suppression of HNF-1β in the HNF-1β-overexpressing human ovarian cancer cell line RMG2 using short hairpin RNA resulted in a significant increase in proliferation. It also facilitated glucose uptake, glycolytic activity, and lactate secretion along with increased expression of the glucose transporter-1 (GLUT-1) gene and several key enzymes in the glycolytic process. Conversely, forced expression of HNF-1β in the serous ovarian cancer cell line, Hey, resulted in slowed cellular growth and repressed glycolytic activity. These data suggest that HNF-1β represses cell growth, and at the same time, it promotes aerobic glycolysis which is known as the "Warburg effect." As the Warburg effect is regarded as a characteristic metabolic process in cancer which may contribute to cell survival under hypoxic conditions or in a stressful environment, overexpression of HNF-1β may play an inevitable role in the occurrence of OCCC in stressful environment.
[frequency of next (right) word to gene]
(1)75 expression (15)5 of (29)3 block (43)2 mutation
(2)34 order (16)5 transfer (30)3 can (44)2 on
(3)32 arrangement (17)5 were (31)3 contents (45)2 overlap
(4)31 and (18)4 activation (32)3 polymorphisms (46)2 peptide
(5)21 *null* (19)4 delivery (33)3 sequencing (47)2 profiling
(6)15 was (20)4 encoding (34)3 transcription (48)2 regions
(7)12 expression, (21)4 expressions (35)2 analysis (49)2 sequence
(8)9 arrangement, (22)4 fragments (36)2 carriers (50)2 sequences,
(9)7 composition (23)4 is (37)2 cluster (51)2 spookier
(10)7 organization (24)4 silencing (38)2 clusters (52)2 synteny
(11)7 sequences (25)4 to (39)2 content (53)2 therapy,
(12)5 flow (26)4 which (40)2 family (54)2 used
(13)5 for (27)3 alterations (41)2 from (55)2 uses
(14)5 in (28)3 as (42)2 has

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--- WordNet output for gene --- =>遺伝子 Overview of noun gene The noun gene has 1 sense (no senses from tagged texts) 1. gene, cistron, factor -- ((genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors") --- WordNet end ---