ELIZA

return kwic search for genes out of >500 occurrences
299409 occurrences (No.76 in the rank) during 5 years in the PubMed. [no cache] 500 found

192) To identify predictive factors for BRCA1/2 mutations, we screened the entire coding sequences and intron/exon boundaries of BRCA1/BRCA2 genes in 48 patients by direct sequencing.

--- ABSTRACT ---

PMID:24372583 DOI:10.1111/cge.12337

2015 Clinical genetics

* Mutation spectrum and prevalence of BRCA1 and BRCA2 genes in patients with familial and early-onset breast/ovarian cancer from Tunisia.

- The contribution of BRCA1/BRCA2 mutations to hereditary breast cancer in the Tunisian population has not been accurately estimated. The purpose of our study was to estimate the incidence and spectrum of pathogenic mutations in BRCA1/2 genes in early onset and familial breast/ovarian cancer among Tunisian women. To identify predictive factors for BRCA1/2 mutations, we screened the entire coding sequences and intron/exon boundaries of BRCA1/BRCA2 genes in 48 patients by direct sequencing. Twelve pathogenic mutations were detected (25%); three in BRCA1 (c.211dupA in four families, c.5266dupC in three families and c.1504_1508delTTAAA in one family) and two novel mutations in BRCA2 (c.1313dupT in two families and c.7654dupT in two families). We also identified 23 different polymorphisms and unclassified variants. These results indicate that our population has a spectrum of recurrent BRCA mutations.

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(1)101 and	(12)8 including	(23)4 for	(34)2 13
(2)36 null	(13)7 encoding	(24)4 from	(35)2 but
(3)28 are	(14)7 involved	(25)4 related	(36)2 can
(4)26 were	(15)7 which	(26)4 with	(37)2 coding
(5)25 in	(16)6 (PCGs),	(27)3 had	(38)2 expressed
(6)16 2	(17)6 use	(28)3 have	(39)2 is
(7)14 (13	(18)5 may	(29)3 stop	(40)2 on
(8)14 22	(19)5 that	(30)3 such	(41)2 ranged
(9)12 start	(20)4 (PCGs)	(31)2 (cytb,	(42)2 to
(10)11 of	(21)4 as	(32)2 (pnad1
(11)9 was	(22)4 associated	(33)2 (srfAA,

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--- WordNet output for genes --- =>発生, 起源, 起こり, 生成, 創始, 創世記 Overview of noun gene The noun gene has 1 sense (no senses from tagged texts) 1. gene, cistron, factor -- ((genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors") --- WordNet end ---