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385944 occurrences (No.46 in the rank) during 5 years in the PubMed. [no cache] 500 found

24) Pretreatment of MESM ameliorated acrylamide-induced behavioral, biochemical, and histopathological changes in a dose-dependent manner, which is similar to that of pregabalin-pretreated group.

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PMID:23719848 DOI:10.1177/0748233713491808

2015 Toxicology and industrial health

* Pharmacological evaluation of methanolic leaf extract of Swietenia mahagoni on acrylamide-induced neuropathic pain in rats.

- The present study was designed to investigate the antinociceptive effects of methanolic leaf extract of Swietenia mahagoni (MESM) on acrylamide-induced painful neuropathy in rats. The intraperitoneal administration of acrylamide (30 mg/kg; for 24 consecutive days) has been employed for the induction of painful neuropathy. Acrylamide induced nociceptive pain sensitive changes, which have been assessed by hot plate, Von Frey Hair, and tail immersion tests at different time intervals, that is, 0, 6, 12, 18, and 24th day. Furthermore, the biochemical changes, that is, thiobarbituric acid-reactive substances, reduced glutathione, and total calcium levels have been estimated in sciatic nerve tissue on 24th day and histopathological changes have been observed in sciatic nerve tissue sample. MESM and pregabalin have been administered for 14 consecutive days before 1 h of the each acrylamide injection. Administration of acrylamide resulted in significant changes in behavioral and biochemical parameters. Pretreatment of MESM ameliorated acrylamide-induced behavioral, biochemical, and histopathological changes in a dose-dependent manner, which is similar to that of pregabalin-pretreated group. These findings suggested that the neuroprotective effect of S. mahagoni may be due to its potential of antioxidative, calcium channel modulatory, and neuroprotective action.

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(1)49 null	(15)7 received	(29)3 II	(44)2 difference
(2)33 was	(16)5 at	(30)3 after	(45)2 displayed
(3)29 and	(17)5 for	(31)3 comprised	(46)2 dynamics-based
(4)25 of	(18)5 the	(32)3 in	(47)2 exhibited
(5)16 compared	(19)5 to	(33)3 when	(48)2 however,
(6)12 A	(20)4 (p	(34)2 (30	(49)2 improved
(7)12 were	(21)4 B	(35)2 (n	(50)2 included
(8)11 discussions	(22)4 C	(37)2 B,	(51)2 intervention
(9)10 than	(23)4 differences	(38)2 III	(52)2 interventions
(10)9 I	(24)4 or	(39)2 V	(53)2 interviews
(11)8 had	(25)3 1,	(40)2 a	(54)2 patients
(12)8 showed	(26)3 2	(41)2 as	(55)2 presented
(13)8 with	(27)3 4	(42)2 contains	(56)2 that
(14)7 1	(28)3 A,	(43)2 demonstrated

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--- WordNet output for group --- =>一団にする, 集める, 分派, 集団, グループ, 分類する, 演奏家グループ, 集まる, 分ける Overview of noun group The noun group has 3 senses (first 2 from tagged texts) 1. (1345) group, grouping -- (any number of entities (members) considered as a unit) 2. (1) group, radical, chemical group -- ((chemistry) two or more atoms bound together as a single unit and forming part of a molecule) 3. group, mathematical group -- (a set that is closed, associative, has an identity element and every element has an inverse) Overview of verb group The verb group has 2 senses (first 2 from tagged texts) 1. (4) group -- (arrange into a group or groups; "Can you group these shapes together?") 2. (1) group, aggroup -- (form a group or group together) --- WordNet end ---