ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for growth out of >500 occurrences
309169 occurrences (No.70 in the rank) during 5 years in the PubMed. [no cache] 500 found
33) Furthermore, miR-106b mediates TGF-β effects on tumor growth and metastasis in breast cancer xenografts.
--- ABSTRACT ---
PMID:24292682 DOI:10.1038/onc.2013.525
2015 Oncogene
* MiR-106b expression determines the proliferation paradox of TGF-β in breast cancer cells.
- TGF-β has paradoxical effects on cancer cell proliferation, as it suppresses proliferation of normal epithelial and low-invasive cancer cells, but enhances that of high-invasive cancer cells. However, how cancer cells acquire the ability to evade the tumor-suppressing effects of TGF-β, yet still take advantage of its tumor-promoting effects, remains elusive. Here, we identified miR-106b as a molecular switch to determine TGF-β effects on cell proliferation. TGF-β1 enhances the transcription of miR-106b via a promoter independent of its host gene MCM7 by activating c-jun. In high-invasive breast cancer cells, miR-106b is upregulated by TGF-β1 at a much higher level than that in normal or low-invasive cancer cells. Accumulation of miR-106b counterbalances TGF-β growth-inhibiting effects by eliminating activated retinoblastoma (RB) and results in enhanced proliferation. Furthermore, miR-106b mediates TGF-β effects on tumor growth and metastasis in breast cancer xenografts. In addition, miR-106b expression is elevated in higher stage tumors and correlated with tumor progression in breast cancer patients. These findings suggest that high level of miR-106b induced by TGF-β determines the tumor-promoting effects of TGF-β in breast cancer.
--- ABSTRACT END ---
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[frequency of next (right) word to growth]
(1)69 and (12)5 at (25)3 models (36)2 model
(2)48 factor (13)4 but (26)3 or (37)2 modeling
(3)48 of (14)4 during (27)3 traits (38)2 outcomes
(4)41 *null* (15)4 factor, (28)3 trajectories (39)2 phase
(5)32 in (17)4 patterns (29)2 among (40)2 properties
(6)25 factors (18)4 plate (30)2 are (41)2 responses
(7)9 inhibition (19)4 response (31)2 as (42)2 restriction
(8)8 rate (20)4 was (32)2 dynamics (43)2 stunting
(9)6 factors, (21)3 cone (33)2 effects (44)2 to
(10)6 rates (22)3 curve (34)2 forest (45)2 velocities
(11)5 arrest (23)3 factor-C (35)2 hormone (46)2 were

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--- WordNet output for growth --- =>茂み, 成長, 増加, 発展, 栽培, 腫よう, 成長物 Overview of noun growth The noun growth has 7 senses (first 5 from tagged texts) 1. (37) growth, growing, maturation, development, ontogeny, ontogenesis -- ((biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level; "he proposed an indicator of osseous development in children") 2. (20) growth -- (a progression from simpler to more complex forms; "the growth of culture") 3. (3) increase, increment, growth -- (a process of becoming larger or longer or more numerous or more important; "the increase in unemployment"; "the growth of population") 4. (3) growth -- (vegetation that has grown; "a growth of trees"; "the only growth was some salt grass") 5. (1) emergence, outgrowth, growth -- (the gradual beginning or coming forth; "figurines presage the emergence of sculpture in Greece") 6. growth -- ((pathology) an abnormal proliferation of tissue (as in a tumor)) 7. growth -- (something grown or growing; "a growth of hair") --- WordNet end ---