ELIZA

return kwic search for higher out of >500 occurrences
487192 occurrences (No.29 in the rank) during 5 years in the PubMed. [cache]

18) The 6-MP dose administered to patients with ALL with a NUDT15 variant was higher than that given to those without SMNs (P = .045).

--- ABSTRACT ---

PMID:34662904 DOI:10.1182/bloodadvances.2021005507

2021 Blood advances

* NUDT15 variants confer high incidence of second malignancies in children with acute lymphoblastic leukemia.

- The effect of genetic variation on second malignant neoplasms (SMNs) remains unclear. First, we identified the pathogenic germline variants in cancer-predisposing genes among 15 children with SMNs after childhood leukemia/lymphoma using whole-exome sequencing. Because the prevalence was low, we focused on the association between SMNs and NUDT15 in primary acute lymphoblastic leukemia (ALL) cases. NUDT15 is one of the 6-mercaptopurine (6-MP) metabolic genes, and its variants are common in East Asian individuals. The prevalence of NUDT15 hypomorphic variants was higher in patients with SMNs (n = 14; 42.9%) than in the general population in the gnomAD database (19.7%; P = .042). In the validation study with a cohort of 438 unselected patients with ALL, the cumulative incidence of SMNs was significantly higher among those with (3.0%; 95% confidence interval [CI], 0.6% to 9.4%) than among those without NUDT15 variants (0.3%; 95% CI, 0.0% to 1.5%; P = .045). The 6-MP dose administered to patients with ALL with a NUDT15 variant was higher than that given to those without SMNs (P = .045). The 6-MP-related mutational signature was observed in SMN specimens after 6-MP exposure. In cells exposed to 6-MP, a higher level of 6-MP induced DNA damage in NUDT15-knockdown induced pluripotent stem cells. Our study indicates that NUDT15 variants may confer a risk of SMNs after treatment with 6-MP in patients with ALL.

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(1)37 than	(14)5 mortality	(27)2 activation	(40)2 or
(2)33 in	(15)4 concentrations	(28)2 anti-E	(41)2 percentage
(3)28 levels	(16)4 proportion	(29)2 at	(42)2 performing
(4)27 risk	(17)4 rate	(30)2 auditory-perceptual	(43)2 potency
(5)11 rates	(18)4 regions	(31)2 cognitive	(44)2 risk,
(6)10 among	(19)3 consumption	(32)2 compared	(45)2 scores
(7)8 for	(20)3 frequency	(33)2 disease	(46)2 selectivity
(8)8 prevalence	(21)3 plasma	(34)2 doses	(47)2 social
(9)7 education	(22)3 quality	(35)2 endostatin	(48)2 stimulation
(10)7 level	(23)3 sensitivity	(36)2 extent	(49)2 to
(11)6 expression	(24)3 strength	(37)2 from	(50)2 tumor
(12)5 and	(25)2 F	(38)2 glutamate-cysteine	(51)2 weight
(13)5 incidence	(26)2 NAFLD	(39)2 odds

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--- WordNet output for higher --- =>幹部, おえら方 Overview of adj higher The adj higher has 2 senses (first 2 from tagged texts) 1. (10) higher -- (advanced in complexity or elaboration; "higher finance"; "higher mathematics") 2. (1) higher -- (of education beyond the secondary level; "higher education"; "higher learning") Overview of adj high The adj high has 7 senses (first 5 from tagged texts) 1. (134) high -- (greater than normal in degree or intensity or amount; "a high temperature"; "a high price"; "the high point of his career"; "high risks"; "has high hopes"; "the river is high"; "he has a high opinion of himself") 2. (51) high -- ((literal meaning) being at or having a relatively great or specific elevation or upward extension (sometimes used in combinations like `knee-high'); "a high mountain"; "high ceilings"; "high buildings"; "a high forehead"; "a high incline"; "a foot high") 3. (10) eminent, high -- (standing above others in quality or position; "people in high places"; "the high priest"; "eminent members of the community") 4. (7) high, high-pitched -- (used of sounds and voices; high in pitch or frequency) 5. (2) high, in high spirits -- (happy and excited and energetic) 6. gamey, gamy, high -- ((used of the smell of meat) smelling spoiled or tainted) 7. high, mellow -- (slightly and pleasantly intoxicated from alcohol or a drug (especially marijuana)) --- WordNet end ---