ELIZA

return kwic search for higher out of >500 occurrences
487192 occurrences (No.29 in the rank) during 5 years in the PubMed. [cache]

350) Moreover, the in vivo experiments demonstrated that the CuG-DOX exhibited significantly higher anticancer efficiency compared with free DOX.

--- ABSTRACT ---

PMID:34420089 DOI:10.1007/s00775-021-01887-3

2021 Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry

* Cu (II)-porphyrin metal-organic framework/graphene oxide: synthesis, characterization, and application as a pH-responsive drug carrier for breast cancer treatment.

- A new multifunctional graphene oxide/Cu (II)-porphyrin MOF nanocomposite (CuG) comprised of Cu-TCPP MOF supported on graphene oxide (GO) nanosheets, has been fabricated by a solvothermal method at low temperature and one-pot process. Cu-TCPP MOF with universal advantages, such as high porosity, nontoxicity, large surface area, and safe biodegradation, combined with GO allows the achievement of an efficient doxorubicin loading (45.7%) and smart pH-responsive release for chemotherapy. More significantly, more than 97% of DOX was released by CuG at pH 5 which was more than that at pH 7.4 (~ 33.5%), while Cu-TCPP MOF displayed DOX release of 68.5% and 49% at pH 5 and 7.4, respectively, illustrating the effect of GO on the smart MOF construction for controllable releasing behavior in vitro. The results of in vitro anticancer experiments demonstrate that the developed nanocarrier exhibited slight or no cytotoxicity on normal cells, while the drug-loaded nanocarrier increased significant cancer cell-killing ability with higher therapeutic efficacy than free DOX, indicating the sustained release behavior of the CuG nanocarrier without any "burst effect". Moreover, the in vivo experiments demonstrated that the CuG-DOX exhibited significantly higher anticancer efficiency compared with free DOX. High anti-cancer therapeutic efficacy of this nanoscale carrier as an efficient pH sensitive agent, has the potential to enter further biomedical investigations. A new smart multifunctional graphene oxide-Cu (II)-porphyrin MOF nanocomposite (CuG) formed of Cu-TCPP MOF and graphene oxide (GO) has successfully fabricated and demonstrated an efficient pH-responsive drug release behavior in cancer therapy without using any targeting ligand.

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(1)37 than	(14)5 mortality	(27)2 activation	(40)2 or
(2)33 in	(15)4 concentrations	(28)2 anti-E	(41)2 percentage
(3)28 levels	(16)4 proportion	(29)2 at	(42)2 performing
(4)27 risk	(17)4 rate	(30)2 auditory-perceptual	(43)2 potency
(5)11 rates	(18)4 regions	(31)2 cognitive	(44)2 risk,
(6)10 among	(19)3 consumption	(32)2 compared	(45)2 scores
(7)8 for	(20)3 frequency	(33)2 disease	(46)2 selectivity
(8)8 prevalence	(21)3 plasma	(34)2 doses	(47)2 social
(9)7 education	(22)3 quality	(35)2 endostatin	(48)2 stimulation
(10)7 level	(23)3 sensitivity	(36)2 extent	(49)2 to
(11)6 expression	(24)3 strength	(37)2 from	(50)2 tumor
(12)5 and	(25)2 F	(38)2 glutamate-cysteine	(51)2 weight
(13)5 incidence	(26)2 NAFLD	(39)2 odds

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--- WordNet output for higher --- =>幹部, おえら方 Overview of adj higher The adj higher has 2 senses (first 2 from tagged texts) 1. (10) higher -- (advanced in complexity or elaboration; "higher finance"; "higher mathematics") 2. (1) higher -- (of education beyond the secondary level; "higher education"; "higher learning") Overview of adj high The adj high has 7 senses (first 5 from tagged texts) 1. (134) high -- (greater than normal in degree or intensity or amount; "a high temperature"; "a high price"; "the high point of his career"; "high risks"; "has high hopes"; "the river is high"; "he has a high opinion of himself") 2. (51) high -- ((literal meaning) being at or having a relatively great or specific elevation or upward extension (sometimes used in combinations like `knee-high'); "a high mountain"; "high ceilings"; "high buildings"; "a high forehead"; "a high incline"; "a foot high") 3. (10) eminent, high -- (standing above others in quality or position; "people in high places"; "the high priest"; "eminent members of the community") 4. (7) high, high-pitched -- (used of sounds and voices; high in pitch or frequency) 5. (2) high, in high spirits -- (happy and excited and energetic) 6. gamey, gamy, high -- ((used of the smell of meat) smelling spoiled or tainted) 7. high, mellow -- (slightly and pleasantly intoxicated from alcohol or a drug (especially marijuana)) --- WordNet end ---