ELIZA

return kwic search for higher out of >500 occurrences
487192 occurrences (No.29 in the rank) during 5 years in the PubMed. [no cache] 500 found

352) PCL-alginate gels containing transforming growth factor-β (TGFβ) showed higher ECM formation.

--- ABSTRACT ---

PMID:23349081 DOI:10.1002/term.1682

2015 Journal of tissue engineering and regenerative medicine

* An additive manufacturing-based PCL-alginate-chondrocyte bioprinted scaffold for cartilage tissue engineering.

- Regenerative medicine is targeted to improve, restore or replace damaged tissues or organs using a combination of cells, materials and growth factors. Both tissue engineering and developmental biology currently deal with the process of tissue self-assembly and extracellular matrix (ECM) deposition. In this investigation, additive manufacturing (AM) with a multihead deposition system (MHDS) was used to fabricate three-dimensional (3D) cell-printed scaffolds using layer-by-layer (LBL) deposition of polycaprolactone (PCL) and chondrocyte cell-encapsulated alginate hydrogel. Appropriate cell dispensing conditions and optimum alginate concentrations for maintaining cell viability were determined. In vitro cell-based biochemical assays were performed to determine glycosaminoglycans (GAGs), DNA and total collagen contents from different PCL-alginate gel constructs. PCL-alginate gels containing transforming growth factor-β (TGFβ) showed higher ECM formation. The 3D cell-printed scaffolds of PCL-alginate gel were implanted in the dorsal subcutaneous spaces of female nude mice. Histochemical [Alcian blue and haematoxylin and eosin (H&E) staining] and immunohistochemical (type II collagen) analyses of the retrieved implants after 4 weeks revealed enhanced cartilage tissue and type II collagen fibril formation in the PCL-alginate gel (+TGFβ) hybrid scaffold. In conclusion, we present an innovative cell-printed scaffold for cartilage regeneration fabricated by an advanced bioprinting technology.

--- ABSTRACT END ---

[
right
kwic]

[frequency of next (right) word to higher]

(1)69 in	(17)3 body	(33)2 by	(49)2 infant
(2)63 than	(18)3 fatalism	(34)2 concentrations	(50)2 initial
(3)21 levels	(19)3 likelihood	(35)2 coverage	(51)2 mean
(4)17 risk	(20)3 odds	(36)2 degree	(52)2 order
(5)10 level	(21)3 on	(37)2 different	(53)2 physiological
(6)9 among	(22)3 quality	(38)2 dose	(54)2 probability
(7)8 for	(23)2 (odds	(39)2 doses	(55)2 quantity
(8)6 rates	(24)2 null	(40)2 drug	(56)2 rate
(9)5 cell	(25)2 AT	(41)2 during	(57)2 relative
(10)5 potency	(26)2 MTBS	(42)2 education	(58)2 revision
(11)5 scores	(27)2 RDW	(43)2 education,	(59)2 sensitivity
(12)4 compared	(28)2 abstinence	(44)2 expectations	(60)2 stress
(13)4 number	(29)2 adjusted	(45)2 expression	(61)2 to
(14)4 prevalence	(30)2 amount	(46)2 frequency	(62)2 total
(15)3 (P	(31)2 birth	(47)2 incidence	(63)2 values
(16)3 amounts	(32)2 blood	(48)2 individual

add keyword

--- WordNet output for higher --- =>幹部, おえら方 Overview of adj higher The adj higher has 2 senses (first 2 from tagged texts) 1. (10) higher -- (advanced in complexity or elaboration; "higher finance"; "higher mathematics") 2. (1) higher -- (of education beyond the secondary level; "higher education"; "higher learning") Overview of adj high The adj high has 7 senses (first 5 from tagged texts) 1. (134) high -- (greater than normal in degree or intensity or amount; "a high temperature"; "a high price"; "the high point of his career"; "high risks"; "has high hopes"; "the river is high"; "he has a high opinion of himself") 2. (51) high -- ((literal meaning) being at or having a relatively great or specific elevation or upward extension (sometimes used in combinations like `knee-high'); "a high mountain"; "high ceilings"; "high buildings"; "a high forehead"; "a high incline"; "a foot high") 3. (10) eminent, high -- (standing above others in quality or position; "people in high places"; "the high priest"; "eminent members of the community") 4. (7) high, high-pitched -- (used of sounds and voices; high in pitch or frequency) 5. (2) high, in high spirits -- (happy and excited and energetic) 6. gamey, gamy, high -- ((used of the smell of meat) smelling spoiled or tainted) 7. high, mellow -- (slightly and pleasantly intoxicated from alcohol or a drug (especially marijuana)) --- WordNet end ---