ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for human out of >500 occurrences
482327 occurrences (No.32 in the rank) during 5 years in the PubMed. [no cache] 500 found
10) The purpose of these studies was to compare human and canine melanoma tumours and cell lines regarding MAPK and PI3K/AKT signalling dysregulation, and response to select molecularly targeted agents.
--- ABSTRACT ---
PMID:23745794 DOI:10.1111/vco.12044
2015 Veterinary and comparative oncology
* Comparative analysis of MAPK and PI3K/AKT pathway activation and inhibition in human and canine melanoma.
- The lack of advanced animal models of human cancers is considered a barrier to developing effective therapeutics. Canine and human melanomas are histologically disparate but show similar disease progression and response to therapies. The purpose of these studies was to compare human and canine melanoma tumours and cell lines regarding MAPK and PI3K/AKT signalling dysregulation, and response to select molecularly targeted agents. Pathway activation was investigated via microarray and mutational analysis. Growth inhibition and cell cycle effects were assessed for pathway inhibitors AZD6244 (MAPK) and rapamycin (PI3K/AKT) in human and canine melanoma cells. Human and canine melanoma share similar differential gene expression patterns within the MAPK and PI3K/AKT pathways. Constitutive pathway activation and similar sensitivity to AZD6244 and rapamycin was observed in human and canine cells. These results show that human and canine melanoma share activation and sensitivity to inhibition of cancer-related signalling pathways despite differences in activating mutations.
--- ABSTRACT END ---
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[frequency of next (right) word to human]
(1)19 and (23)3 blood (45)2 adipose-derived (67)2 insulin
(2)15 health (24)3 bronchial (46)2 amniotic (68)2 interaction
(3)11 brain (25)3 dental (47)2 articular (69)2 islet
(4)10 breast (26)3 dermal (48)2 body, (70)2 leukocyte
(5)8 body (27)3 embryonic (49)2 brain, (71)2 liver
(6)8 mesenchymal (28)3 head (50)2 but (72)2 microbiota
(7)8 papillomavirus (29)3 lung (51)2 cartilage (73)2 mycetoma
(8)7 bone (30)3 nasal (52)2 cerebral (74)2 neuroblastoma
(9)7 subjects (31)3 renal (53)2 chorionic (75)2 oral
(10)7 umbilical (32)3 serum (54)2 consumption, (76)2 osteosarcoma
(11)6 cancer (33)3 skin (55)2 cortical (77)2 papilloma
(12)6 hepatocytes (34)3 spinal (56)2 disease (78)2 participants
(13)4 *null* (35)3 teeth (57)2 endometrial (79)2 periodontal
(14)4 MSCs (36)3 tissues (58)2 endothelial (80)2 platelet
(15)4 cancers (37)2 Alu (59)2 eye (81)2 primary
(16)4 cancers, (38)2 CD34(+) (60)2 face (82)2 resources
(17)4 immunodeficiency (39)2 DMN (61)2 fibroblasts (83)2 respiratory
(18)4 model (40)2 PIF1 (62)2 glioma (84)2 rights
(19)4 oncology (41)2 TP (63)2 health, (85)2 studies
(20)4 plasma (42)2 abdomen (64)2 hepatocellular (86)2 third
(21)3 Province (43)2 activity (65)2 induced (87)2 tooth
(22)3 acellular (44)2 adipose (66)2 infections,

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--- WordNet output for human --- =>人間らしい, 人間の, 人, 人間 Overview of noun human The noun human has 1 sense (first 1 from tagged texts) 1. (5) homo, man, human being, human -- (any living or extinct member of the family Hominidae characterized by superior intelligence, articulate speech, and erect carriage) Overview of adj human The adj human has 3 senses (first 3 from tagged texts) 1. (46) human -- (characteristic of humanity; "human nature") 2. (19) human -- (relating to a person; "the experiment was conducted on 6 monkeys and 2 human subjects") 3. (15) human -- (having human form or attributes as opposed to those of animals or divine beings; "human beings"; "the human body"; "human kindness"; "human frailty") --- WordNet end ---