ELIZA

return kwic search for human out of >500 occurrences
482327 occurrences (No.32 in the rank) during 5 years in the PubMed. [no cache] 500 found

154) The effects of poly(lactic-co-glycolic acid) (PLGA), silica, iron oxide and titanium dioxide NPs were studied using human bronchial (16HBE) and alveolar epithelial cells (A549).

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PMID:24286383 DOI:10.3109/17435390.2013.855830

2015 Nanotoxicology

* Toxicity evaluation of engineered nanoparticles for medical applications using pulmonary epithelial cells.

- There are a multitude of nanoparticles (NPs) which have shown great potentials for medical applications. A few of them are already used for lung therapeutic and diagnostic purposes. However, there are few toxicological studies which determine possible adverse pulmonary responses. It is thus important to propose in vitro screening strategies to evaluate the pulmonary toxicity of NPs used in nanomedicine. Our goal was to determine the cellular effects of several biomedical NPs with different physico-chemical characteristics (chemical nature, size and coating) to establish suitable tests and useful benchmark NPs. The effects of poly(lactic-co-glycolic acid) (PLGA), silica, iron oxide and titanium dioxide NPs were studied using human bronchial (16HBE) and alveolar epithelial cells (A549). We evaluated cytotoxicity, reactive oxygen species (ROS) production and pro-inflammatory response in both cell lines. We demonstrated that PLGA NPs are good candidates for negative control NPs and SiO2 NPs were revealed to be the best benchmark NPs. Coating of Fe3O4 with sodium oleate, a known biocompatible compound, led to an unexpected increase in cytotoxicity. Moreover, 16HBE cells are more sensitive than A549 cells and propidium iodide uptake is a more sensitive cytotoxicity test than WST-1. The measurement of oxidative stress does not systematically allow us to predict cellular responses and different other cellular endpoints should also be addressed. We conclude that a battery of assays and cell lines are necessary to accurately evaluate the pulmonary effects of NPs and that PLGA and SiO2 NPs are suitable candidates respectively for negative and positive controls.

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[frequency of next (right) word to human]

(1)19 and	(23)3 blood	(45)2 adipose-derived	(67)2 insulin
(2)15 health	(24)3 bronchial	(46)2 amniotic	(68)2 interaction
(3)11 brain	(25)3 dental	(47)2 articular	(69)2 islet
(4)10 breast	(26)3 dermal	(48)2 body,	(70)2 leukocyte
(5)8 body	(27)3 embryonic	(49)2 brain,	(71)2 liver
(6)8 mesenchymal	(28)3 head	(50)2 but	(72)2 microbiota
(7)8 papillomavirus	(29)3 lung	(51)2 cartilage	(73)2 mycetoma
(8)7 bone	(30)3 nasal	(52)2 cerebral	(74)2 neuroblastoma
(9)7 subjects	(31)3 renal	(53)2 chorionic	(75)2 oral
(10)7 umbilical	(32)3 serum	(54)2 consumption,	(76)2 osteosarcoma
(11)6 cancer	(33)3 skin	(55)2 cortical	(77)2 papilloma
(12)6 hepatocytes	(34)3 spinal	(56)2 disease	(78)2 participants
(13)4 null	(35)3 teeth	(57)2 endometrial	(79)2 periodontal
(14)4 MSCs	(36)3 tissues	(58)2 endothelial	(80)2 platelet
(15)4 cancers	(37)2 Alu	(59)2 eye	(81)2 primary
(16)4 cancers,	(38)2 CD34(+)	(60)2 face	(82)2 resources
(17)4 immunodeficiency	(39)2 DMN	(61)2 fibroblasts	(83)2 respiratory
(18)4 model	(40)2 PIF1	(62)2 glioma	(84)2 rights
(19)4 oncology	(41)2 TP	(63)2 health,	(85)2 studies
(20)4 plasma	(42)2 abdomen	(64)2 hepatocellular	(86)2 third
(21)3 Province	(43)2 activity	(65)2 induced	(87)2 tooth
(22)3 acellular	(44)2 adipose	(66)2 infections,

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--- WordNet output for human --- =>人間らしい, 人間の, 人, 人間 Overview of noun human The noun human has 1 sense (first 1 from tagged texts) 1. (5) homo, man, human being, human -- (any living or extinct member of the family Hominidae characterized by superior intelligence, articulate speech, and erect carriage) Overview of adj human The adj human has 3 senses (first 3 from tagged texts) 1. (46) human -- (characteristic of humanity; "human nature") 2. (19) human -- (relating to a person; "the experiment was conducted on 6 monkeys and 2 human subjects") 3. (15) human -- (having human form or attributes as opposed to those of animals or divine beings; "human beings"; "the human body"; "human kindness"; "human frailty") --- WordNet end ---