ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for human out of >500 occurrences
482327 occurrences (No.32 in the rank) during 5 years in the PubMed. [cache]
17) Passage 3, 5 and 7 (P3, P5 and P7) human and ovine vascular-derived cells were seeded onto both PGA-P4HB and PCL scaffold strips.
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PMID:23677869 DOI:10.1002/term.1753
2015 Journal of tissue engineering and regenerative medicine
* Poly-ε-caprolactone scaffold and reduced in vitro cell culture: beneficial effect on compaction and improved valvular tissue formation.
- Tissue-engineered heart valves (TEHVs), based on polyglycolic acid (PGA) scaffolds coated with poly-4-hydroxybutyrate (P4HB), have shown promising in vivo results in terms of tissue formation. However, a major drawback of these TEHVs is compaction and retraction of the leaflets, causing regurgitation. To overcome this problem, the aim of this study was to investigate: (a) the use of the slowly degrading poly-ε-caprolactone (PCL) scaffold for prolonged mechanical integrity; and (b) the use of lower passage cells for enhanced tissue formation. Passage 3, 5 and 7 (P3, P5 and P7) human and ovine vascular-derived cells were seeded onto both PGA-P4HB and PCL scaffold strips. After 4 weeks of culture, compaction, tissue formation, mechanical properties and cell phenotypes were compared. TEHVs were cultured to observe retraction of the leaflets in the native-like geometry. After culture, tissues based on PGA-P4HB scaffold showed 50-60% compaction, while PCL-based tissues showed compaction of 0-10%. Tissue formation, stiffness and strength were increased with decreasing passage number; however, this did not influence compaction. Ovine PCL-based tissues did render less strong tissues compared to PGA-P4HB-based tissues. No differences in cell phenotype between the scaffold materials, species or cell passage numbers were observed. This study shows that PCL scaffolds may serve as alternative scaffold materials for human TEHVs with minimal compaction and without compromising tissue composition and properties, while further optimization of ovine TEHVs is needed. Reducing cell expansion time will result in faster generation of TEHVs, providing more rapid treatment for patients.
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[frequency of next (right) word to human]
(1)19 and (23)3 blood (45)2 adipose-derived (67)2 insulin
(2)15 health (24)3 bronchial (46)2 amniotic (68)2 interaction
(3)11 brain (25)3 dental (47)2 articular (69)2 islet
(4)10 breast (26)3 dermal (48)2 body, (70)2 leukocyte
(5)8 body (27)3 embryonic (49)2 brain, (71)2 liver
(6)8 mesenchymal (28)3 head (50)2 but (72)2 microbiota
(7)8 papillomavirus (29)3 lung (51)2 cartilage (73)2 mycetoma
(8)7 bone (30)3 nasal (52)2 cerebral (74)2 neuroblastoma
(9)7 subjects (31)3 renal (53)2 chorionic (75)2 oral
(10)7 umbilical (32)3 serum (54)2 consumption, (76)2 osteosarcoma
(11)6 cancer (33)3 skin (55)2 cortical (77)2 papilloma
(12)6 hepatocytes (34)3 spinal (56)2 disease (78)2 participants
(13)4 *null* (35)3 teeth (57)2 endometrial (79)2 periodontal
(14)4 MSCs (36)3 tissues (58)2 endothelial (80)2 platelet
(15)4 cancers (37)2 Alu (59)2 eye (81)2 primary
(16)4 cancers, (38)2 CD34(+) (60)2 face (82)2 resources
(17)4 immunodeficiency (39)2 DMN (61)2 fibroblasts (83)2 respiratory
(18)4 model (40)2 PIF1 (62)2 glioma (84)2 rights
(19)4 oncology (41)2 TP (63)2 health, (85)2 studies
(20)4 plasma (42)2 abdomen (64)2 hepatocellular (86)2 third
(21)3 Province (43)2 activity (65)2 induced (87)2 tooth
(22)3 acellular (44)2 adipose (66)2 infections,

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--- WordNet output for human --- =>人間らしい, 人間の, 人, 人間 Overview of noun human The noun human has 1 sense (first 1 from tagged texts) 1. (5) homo, man, human being, human -- (any living or extinct member of the family Hominidae characterized by superior intelligence, articulate speech, and erect carriage) Overview of adj human The adj human has 3 senses (first 3 from tagged texts) 1. (46) human -- (characteristic of humanity; "human nature") 2. (19) human -- (relating to a person; "the experiment was conducted on 6 monkeys and 2 human subjects") 3. (15) human -- (having human form or attributes as opposed to those of animals or divine beings; "human beings"; "the human body"; "human kindness"; "human frailty") --- WordNet end ---