ELIZA

return kwic search for human out of >500 occurrences
482327 occurrences (No.32 in the rank) during 5 years in the PubMed. [cache]

179) SGs have become important players in human health, in addition to their fundamental role in the stress response.

--- ABSTRACT ---

PMID:34604242 DOI:10.3389/fcell.2021.745394

2021 Frontiers in cell and developmental biology

* Stress Granules Involved in Formation, Progression and Metastasis of Cancer: A Scoping Review.

- The assembly of stress granules (SGs) is a well-known cellular strategy for reducing stress-related damage and promoting cell survival. SGs have become important players in human health, in addition to their fundamental role in the stress response. The critical role of SGs in cancer cells in formation, progression, and metastasis makes sense. Recent researchers have found that several SG components play a role in tumorigenesis and cancer metastasis via tumor-associated signaling pathways and other mechanisms. Gene-ontology analysis revealed the role of these protein components in the structure of SGs. Involvement in the translation process, regulation of mRNA stability, and action in both the cytoplasm and nucleus are among the main features of SG proteins. The present scoping review aimed to consider all studies on the effect of SGs on cancer formation, proliferation, and metastasis and performed based on a six-stage methodology structure and the PRISMA guideline. A systematic search of seven databases for qualified articles was conducted before July 2021. Publications were screened, and quantitative and qualitative analysis was performed on the extracted data. Go analysis was performed on seventy-one SGs protein components. Remarkably G3BP1, TIA1, TIAR, and YB1 have the largest share among the proteins considered in the studies. Altogether, this scoping review tries to demonstrate and provide a comprehensive summary of the role of SGs in the formation, progression, and metastasis of cancer by reviewing all studies.

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[frequency of next (right) word to human]

(1)29 health	(21)4 laboratory	(41)2 MC	(61)2 leukocyte
(2)25 and	(22)4 liver	(42)2 PSCs	(62)2 lifespan
(3)10 hepatocytes	(23)4 serum	(43)2 RNA	(63)2 may
(4)9 brain	(24)3 beings	(44)2 activities	(64)2 medicine
(5)9 gut	(25)3 health,	(45)2 adipocytes	(65)2 microbiome
(6)8 studies	(26)3 hepatocyte	(46)2 behavior	(66)2 movement,
(7)7 milk	(27)3 infection	(47)2 behaviour	(67)2 nervous
(8)6 exposure	(28)3 jejunum	(48)2 blood	(68)2 or
(9)6 immunodeficiency	(29)3 livers	(49)2 cell	(69)2 participants,
(10)6 skin	(30)3 lung	(50)2 cerebral	(70)2 pathogen
(11)5 body	(31)3 macrophages	(51)2 colonoids	(71)2 populations,
(12)5 clinical	(32)3 oral	(52)2 data	(72)2 primate
(13)5 disease	(33)3 participants	(53)2 diseases,	(73)2 ratings
(14)5 diseases	(34)3 plasma	(54)2 genome	(74)2 research
(15)5 interaction	(35)3 seasonal	(55)2 genomic	(75)2 resources,
(16)5 papillomavirus	(36)2 ALDH1A3	(56)2 hepatocytes,	(76)2 studies,
(17)5 subjects	(37)2 AV	(57)2 hepatoma	(77)2 trials
(18)4 breast	(38)2 Biomonitoring	(58)2 immune	(78)2 umbilical
(19)4 bronchial	(39)2 CRC	(59)2 induced
(20)4 intestinal	(40)2 Genome	(60)2 interactions

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--- WordNet output for human --- =>人間らしい, 人間の, 人, 人間 Overview of noun human The noun human has 1 sense (first 1 from tagged texts) 1. (5) homo, man, human being, human -- (any living or extinct member of the family Hominidae characterized by superior intelligence, articulate speech, and erect carriage) Overview of adj human The adj human has 3 senses (first 3 from tagged texts) 1. (46) human -- (characteristic of humanity; "human nature") 2. (19) human -- (relating to a person; "the experiment was conducted on 6 monkeys and 2 human subjects") 3. (15) human -- (having human form or attributes as opposed to those of animals or divine beings; "human beings"; "the human body"; "human kindness"; "human frailty") --- WordNet end ---