ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for human out of >500 occurrences
482327 occurrences (No.32 in the rank) during 5 years in the PubMed. [cache]
19) Based on the information both the human and rat BRCA-1 genes harbor xenobiotic responsive elements (XRE = 5'-GCGTG-3'), which are binding targets for the AhR, we extended our studies to the analysis of offspring of pregnant Sprague-Dawley rats treated during gestation with TCDD alone or in combination with the dietary AhR antagonist resveratrol (Res).
--- ABSTRACT ---
PMID:24136580 DOI:10.1002/mc.22095
2015 Molecular carcinogenesis
* Gestational exposure to the AhR agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin induces BRCA-1 promoter hypermethylation and reduces BRCA-1 expression in mammary tissue of rat offspring: preventive effects of resveratrol.
- Studies with murine models suggest that maternal exposure to aromatic hydrocarbon receptor (AhR) agonists may impair mammary gland differentiation and increase the susceptibility to mammary carcinogenesis in offspring. However, the molecular mechanisms responsible for these perturbations remain largely unknown. Previously, we reported that the AhR agonists 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced CpG methylation of the breast cancer-1 (BRCA-1) gene and reduced BRCA-1 expression in breast cancer cell lines. Based on the information both the human and rat BRCA-1 genes harbor xenobiotic responsive elements (XRE = 5'-GCGTG-3'), which are binding targets for the AhR, we extended our studies to the analysis of offspring of pregnant Sprague-Dawley rats treated during gestation with TCDD alone or in combination with the dietary AhR antagonist resveratrol (Res). We report that the in utero exposure to TCDD increased the number of terminal end buds (TEB) and reduced BRCA-1 expression in mammary tissue of offspring. The treatment with TCDD induced occupancy of the BRCA-1 promoter by DNA methyltransferase-1 (DNMT-1), CpG methylation of the BRCA-1 promoter, and expression of cyclin D1 and cyclin-dependent kinase-4 (CDK4). These changes were partially overridden by pre-exposure to Res, which stimulated the expression of the AhR repressor (AhRR) and its recruitment to the BRCA-1 gene. These findings point to maternal exposure to AhR agonists as a risk factor for breast cancer in offspring through epigenetic inhibition of BRCA-1 expression, whereas dietary antagonists of the AhR may exert protective effects.
--- ABSTRACT END ---
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[frequency of next (right) word to human]
(1)19 and (23)3 blood (45)2 adipose-derived (67)2 insulin
(2)15 health (24)3 bronchial (46)2 amniotic (68)2 interaction
(3)11 brain (25)3 dental (47)2 articular (69)2 islet
(4)10 breast (26)3 dermal (48)2 body, (70)2 leukocyte
(5)8 body (27)3 embryonic (49)2 brain, (71)2 liver
(6)8 mesenchymal (28)3 head (50)2 but (72)2 microbiota
(7)8 papillomavirus (29)3 lung (51)2 cartilage (73)2 mycetoma
(8)7 bone (30)3 nasal (52)2 cerebral (74)2 neuroblastoma
(9)7 subjects (31)3 renal (53)2 chorionic (75)2 oral
(10)7 umbilical (32)3 serum (54)2 consumption, (76)2 osteosarcoma
(11)6 cancer (33)3 skin (55)2 cortical (77)2 papilloma
(12)6 hepatocytes (34)3 spinal (56)2 disease (78)2 participants
(13)4 *null* (35)3 teeth (57)2 endometrial (79)2 periodontal
(14)4 MSCs (36)3 tissues (58)2 endothelial (80)2 platelet
(15)4 cancers (37)2 Alu (59)2 eye (81)2 primary
(16)4 cancers, (38)2 CD34(+) (60)2 face (82)2 resources
(17)4 immunodeficiency (39)2 DMN (61)2 fibroblasts (83)2 respiratory
(18)4 model (40)2 PIF1 (62)2 glioma (84)2 rights
(19)4 oncology (41)2 TP (63)2 health, (85)2 studies
(20)4 plasma (42)2 abdomen (64)2 hepatocellular (86)2 third
(21)3 Province (43)2 activity (65)2 induced (87)2 tooth
(22)3 acellular (44)2 adipose (66)2 infections,

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--- WordNet output for human --- =>人間らしい, 人間の, 人, 人間 Overview of noun human The noun human has 1 sense (first 1 from tagged texts) 1. (5) homo, man, human being, human -- (any living or extinct member of the family Hominidae characterized by superior intelligence, articulate speech, and erect carriage) Overview of adj human The adj human has 3 senses (first 3 from tagged texts) 1. (46) human -- (characteristic of humanity; "human nature") 2. (19) human -- (relating to a person; "the experiment was conducted on 6 monkeys and 2 human subjects") 3. (15) human -- (having human form or attributes as opposed to those of animals or divine beings; "human beings"; "the human body"; "human kindness"; "human frailty") --- WordNet end ---