ELIZA

return kwic search for human out of >500 occurrences
482327 occurrences (No.32 in the rank) during 5 years in the PubMed. [no cache] 500 found

239) The folding of the human cerebral cortex is a highly genetically regulated process that allows for a much larger surface area to fit into the cranial vault and optimizes functional organization.

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PMID:34910505 DOI:10.1126/sciadv.abj9446

2021 Science advances

* The genetic architecture of human cortical folding.

- The folding of the human cerebral cortex is a highly genetically regulated process that allows for a much larger surface area to fit into the cranial vault and optimizes functional organization. Sulcal depth is a robust yet understudied measure of localized folding, previously associated with multiple neurodevelopmental disorders. Here, we report the first genome-wide association study of sulcal depth. Through the multivariate omnibus statistical test (MOSTest) applied to vertex-wise measures from 33,748 U.K. Biobank participants (mean age, 64.3 years; 52.0% female), we identified 856 genome-wide significant loci (P < 5 × 10⁻⁸). Comparisons with cortical thickness and surface area indicated that sulcal depth has higher locus yield, heritability, and effective sample size. There was a large amount of genetic overlap between these traits, with gene-based analyses indicating strong associations with neurodevelopmental processes. Our findings demonstrate sulcal depth is a promising neuroimaging phenotype that may enhance our understanding of cortical morphology.

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(1)29 health	(21)4 laboratory	(41)2 MC	(61)2 leukocyte
(2)25 and	(22)4 liver	(42)2 PSCs	(62)2 lifespan
(3)10 hepatocytes	(23)4 serum	(43)2 RNA	(63)2 may
(4)9 brain	(24)3 beings	(44)2 activities	(64)2 medicine
(5)9 gut	(25)3 health,	(45)2 adipocytes	(65)2 microbiome
(6)8 studies	(26)3 hepatocyte	(46)2 behavior	(66)2 movement,
(7)7 milk	(27)3 infection	(47)2 behaviour	(67)2 nervous
(8)6 exposure	(28)3 jejunum	(48)2 blood	(68)2 or
(9)6 immunodeficiency	(29)3 livers	(49)2 cell	(69)2 participants,
(10)6 skin	(30)3 lung	(50)2 cerebral	(70)2 pathogen
(11)5 body	(31)3 macrophages	(51)2 colonoids	(71)2 populations,
(12)5 clinical	(32)3 oral	(52)2 data	(72)2 primate
(13)5 disease	(33)3 participants	(53)2 diseases,	(73)2 ratings
(14)5 diseases	(34)3 plasma	(54)2 genome	(74)2 research
(15)5 interaction	(35)3 seasonal	(55)2 genomic	(75)2 resources,
(16)5 papillomavirus	(36)2 ALDH1A3	(56)2 hepatocytes,	(76)2 studies,
(17)5 subjects	(37)2 AV	(57)2 hepatoma	(77)2 trials
(18)4 breast	(38)2 Biomonitoring	(58)2 immune	(78)2 umbilical
(19)4 bronchial	(39)2 CRC	(59)2 induced
(20)4 intestinal	(40)2 Genome	(60)2 interactions

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--- WordNet output for human --- =>人間らしい, 人間の, 人, 人間 Overview of noun human The noun human has 1 sense (first 1 from tagged texts) 1. (5) homo, man, human being, human -- (any living or extinct member of the family Hominidae characterized by superior intelligence, articulate speech, and erect carriage) Overview of adj human The adj human has 3 senses (first 3 from tagged texts) 1. (46) human -- (characteristic of humanity; "human nature") 2. (19) human -- (relating to a person; "the experiment was conducted on 6 monkeys and 2 human subjects") 3. (15) human -- (having human form or attributes as opposed to those of animals or divine beings; "human beings"; "the human body"; "human kindness"; "human frailty") --- WordNet end ---