ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for human out of >500 occurrences
482327 occurrences (No.32 in the rank) during 5 years in the PubMed. [cache]
27) However, the environmental and human health effects of Ni NPs have not been fully investigated.
--- ABSTRACT ---
PMID:23776134 DOI:10.1002/tox.21879
2015 Environmental toxicology
* Concentration-dependent induction of reactive oxygen species, cell cycle arrest and apoptosis in human liver cells after nickel nanoparticles exposure.
- Due to advent of nanotechnology, nickel nanoparticles (Ni NPs) are increasingly recognized for their utility in various applications including catalysts, sensors and electronics. However, the environmental and human health effects of Ni NPs have not been fully investigated. In this study, we examined toxic effects of Ni NPs in human liver (HepG2) cells. Ni NPs were prepared and characterized by X-ray diffraction, transmission electron microscopy and dynamic light scattering. We observed that Ni NPs (size, ∼28 nm; concentration range, 25-100 μg/mL) induced cytotoxicity in HepG2 cells and degree of induction was concentration-dependent. Ni NPs were also found to induce oxidative stress in dose-dependent manner evident by induction of reactive oxygen species and depletion of glutathione. Cell cycle analysis of cells treated with Ni NPs exhibited significant increase of apoptotic cell population in subG1 phase. Ni NPs also induced caspase-3 enzyme activity and apoptotic DNA fragmentation. Upregulation of cell cycle checkpoint gene p53 and bax/bcl-2 ratio with a concomitant loss in mitochondrial membrane potential suggested that Ni NPs induced apoptosis in HepG2 cells was mediated through mitochondrial pathway. This study warrants that applications of Ni NPs should be carefully assessed as to their toxicity to human health.
--- ABSTRACT END ---
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[frequency of next (right) word to human]
(1)19 and (23)3 blood (45)2 adipose-derived (67)2 insulin
(2)15 health (24)3 bronchial (46)2 amniotic (68)2 interaction
(3)11 brain (25)3 dental (47)2 articular (69)2 islet
(4)10 breast (26)3 dermal (48)2 body, (70)2 leukocyte
(5)8 body (27)3 embryonic (49)2 brain, (71)2 liver
(6)8 mesenchymal (28)3 head (50)2 but (72)2 microbiota
(7)8 papillomavirus (29)3 lung (51)2 cartilage (73)2 mycetoma
(8)7 bone (30)3 nasal (52)2 cerebral (74)2 neuroblastoma
(9)7 subjects (31)3 renal (53)2 chorionic (75)2 oral
(10)7 umbilical (32)3 serum (54)2 consumption, (76)2 osteosarcoma
(11)6 cancer (33)3 skin (55)2 cortical (77)2 papilloma
(12)6 hepatocytes (34)3 spinal (56)2 disease (78)2 participants
(13)4 *null* (35)3 teeth (57)2 endometrial (79)2 periodontal
(14)4 MSCs (36)3 tissues (58)2 endothelial (80)2 platelet
(15)4 cancers (37)2 Alu (59)2 eye (81)2 primary
(16)4 cancers, (38)2 CD34(+) (60)2 face (82)2 resources
(17)4 immunodeficiency (39)2 DMN (61)2 fibroblasts (83)2 respiratory
(18)4 model (40)2 PIF1 (62)2 glioma (84)2 rights
(19)4 oncology (41)2 TP (63)2 health, (85)2 studies
(20)4 plasma (42)2 abdomen (64)2 hepatocellular (86)2 third
(21)3 Province (43)2 activity (65)2 induced (87)2 tooth
(22)3 acellular (44)2 adipose (66)2 infections,

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--- WordNet output for human --- =>人間らしい, 人間の, 人, 人間 Overview of noun human The noun human has 1 sense (first 1 from tagged texts) 1. (5) homo, man, human being, human -- (any living or extinct member of the family Hominidae characterized by superior intelligence, articulate speech, and erect carriage) Overview of adj human The adj human has 3 senses (first 3 from tagged texts) 1. (46) human -- (characteristic of humanity; "human nature") 2. (19) human -- (relating to a person; "the experiment was conducted on 6 monkeys and 2 human subjects") 3. (15) human -- (having human form or attributes as opposed to those of animals or divine beings; "human beings"; "the human body"; "human kindness"; "human frailty") --- WordNet end ---