ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for human out of >500 occurrences
482327 occurrences (No.32 in the rank) during 5 years in the PubMed. [no cache] 500 found
7) The aim of the present research was to demonstrate the presence of TRPV1 in human and canine mammary cancer cells, MCF-7 and CF.41, respectively, and to study the role of TRPV1 in regulating cell proliferation.
--- ABSTRACT ---
PMID:23510405 DOI:10.1111/vco.12028
2015 Veterinary and comparative oncology
* Expression and functionality of TRPV1 receptor in human MCF-7 and canine CF.41 cells.
- As canine mammary tumours (CMT) and human breast cancer share clinical and prognostic features, the former have been proposed as a model to study carcinogenesis and improved therapeutic treatment in human breast cancer. In recent years, it has been shown that transient receptor potential vanilloid 1 (TRPV1) is expressed in different neoplastic tissues and its activation has been associated with regulation of cancer growth and progression. The aim of the present research was to demonstrate the presence of TRPV1 in human and canine mammary cancer cells, MCF-7 and CF.41, respectively, and to study the role of TRPV1 in regulating cell proliferation. The images obtained by Western blot showed a signal at 100 kDa corresponding to the molecular weight of TRPV1 receptor. All tested TRPV1 agonists and antagonists caused a significant decrease (P < 0.05) of cell growth rate in MCF-7 cells. By contrast, in CF.41 cells capsaicin and capsazepine induced a significant increase (P < 0.05) in cell proliferation, whereas resiniferatoxin (RTX) and 5-iodo-resiniferatoxin (5-I-RTX) had no influence on CF.41 cell proliferation. Further studies are needed to elucidate the underlying molecular mechanism responsible for the different effects evoked by TRPV1 activation in MCF-7 and CF.41 cells.
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[frequency of next (right) word to human]
(1)19 and (23)3 blood (45)2 adipose-derived (67)2 insulin
(2)15 health (24)3 bronchial (46)2 amniotic (68)2 interaction
(3)11 brain (25)3 dental (47)2 articular (69)2 islet
(4)10 breast (26)3 dermal (48)2 body, (70)2 leukocyte
(5)8 body (27)3 embryonic (49)2 brain, (71)2 liver
(6)8 mesenchymal (28)3 head (50)2 but (72)2 microbiota
(7)8 papillomavirus (29)3 lung (51)2 cartilage (73)2 mycetoma
(8)7 bone (30)3 nasal (52)2 cerebral (74)2 neuroblastoma
(9)7 subjects (31)3 renal (53)2 chorionic (75)2 oral
(10)7 umbilical (32)3 serum (54)2 consumption, (76)2 osteosarcoma
(11)6 cancer (33)3 skin (55)2 cortical (77)2 papilloma
(12)6 hepatocytes (34)3 spinal (56)2 disease (78)2 participants
(13)4 *null* (35)3 teeth (57)2 endometrial (79)2 periodontal
(14)4 MSCs (36)3 tissues (58)2 endothelial (80)2 platelet
(15)4 cancers (37)2 Alu (59)2 eye (81)2 primary
(16)4 cancers, (38)2 CD34(+) (60)2 face (82)2 resources
(17)4 immunodeficiency (39)2 DMN (61)2 fibroblasts (83)2 respiratory
(18)4 model (40)2 PIF1 (62)2 glioma (84)2 rights
(19)4 oncology (41)2 TP (63)2 health, (85)2 studies
(20)4 plasma (42)2 abdomen (64)2 hepatocellular (86)2 third
(21)3 Province (43)2 activity (65)2 induced (87)2 tooth
(22)3 acellular (44)2 adipose (66)2 infections,

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--- WordNet output for human --- =>人間らしい, 人間の, 人, 人間 Overview of noun human The noun human has 1 sense (first 1 from tagged texts) 1. (5) homo, man, human being, human -- (any living or extinct member of the family Hominidae characterized by superior intelligence, articulate speech, and erect carriage) Overview of adj human The adj human has 3 senses (first 3 from tagged texts) 1. (46) human -- (characteristic of humanity; "human nature") 2. (19) human -- (relating to a person; "the experiment was conducted on 6 monkeys and 2 human subjects") 3. (15) human -- (having human form or attributes as opposed to those of animals or divine beings; "human beings"; "the human body"; "human kindness"; "human frailty") --- WordNet end ---