kwic
identified
identified
right
off
ON
324
1
100
500
strict
ELIZA cgi-bash version rev. 1.91
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
return
kwic search for identified out of >500 occurrences
324223 occurrences (No.64 in the rank) during 5 years in the PubMed. [cache]
--- ABSTRACT ---
--- ABSTRACT END ---
[frequency of next (right) word to identified]
324223 occurrences (No.64 in the rank) during 5 years in the PubMed. [cache]
| 324) In UK Biobank, we identified 1,493 cases of cirrhosis, 12,603 Z allele heterozygotes, and 129 Z allele homozygotes among 312,671 unrelated white British participants. |
| PMID:34430780 DOI:10.1002/hep4.1718 |
| 2021 Hepatology communications |
| * Heterozygosity of the Alpha 1-Antitrypsin Pi*Z Allele and Risk of Liver Disease. |
| - The serpin family A member 1 (SERPINA1) Z allele is present in approximately one in 25 individuals of European ancestry. Z allele homozygosity (Pi*ZZ) is the most common cause of alpha 1-antitrypsin deficiency and is a proven risk factor for cirrhosis. We examined whether heterozygous Z allele (Pi*Z) carriers in United Kingdom (UK) Biobank, a population-based cohort, are at increased risk of liver disease. We replicated findings in Massachusetts General Brigham Biobank, a hospital-based cohort. We also examined variants associated with liver disease and assessed for gene-gene and gene-environment interactions. In UK Biobank, we identified 1,493 cases of cirrhosis, 12,603 Z allele heterozygotes, and 129 Z allele homozygotes among 312,671 unrelated white British participants. Heterozygous carriage of the Z allele was associated with cirrhosis compared to noncarriage (odds ratio [OR], 1.53; P = 1.1×10-04); homozygosity of the Z allele also increased the risk of cirrhosis (OR, 11.8; P = 1.8 × 10-09). The OR for cirrhosis of the Z allele was comparable to that of well-established genetic variants, including patatin-like phospholipase domain containing 3 (PNPLA3) I148M (OR, 1.48; P = 1.1 × 10-22) and transmembrane 6 superfamily member 2 (TM6SF2) E167K (OR, 1.34; P = 2.6 × 10-06). In heterozygotes compared to noncarriers, the Z allele was associated with higher alanine aminotransferase (ALT; P = = 4.6 × 10-46), aspartate aminotransferase (AST; P = 2.2 × 10-27), alkaline phosphatase (P = 3.3 × 10-43), gamma-glutamyltransferase (P = 1.2 × 10-05), and total bilirubin (P = 6.4 × 10-06); Z allele homozygotes had even greater elevations in liver biochemistries. Body mass index (BMI) amplified the association of the Z allele for ALT (P interaction = 0.021) and AST (P interaction = 0.0040), suggesting a gene-environment interaction. Finally, we demonstrated genetic interactions between variants in PNPLA3, TM6SF2, and hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13); there was no evidence of epistasis between the Z allele and these variants. Conclusion: SERPINA1 Z allele heterozygosity is an important risk factor for liver disease; this risk is amplified by increasing BMI. |
[
right
kwic]
| (1)32 *null* | (15)6  several |
(29)2 (1) |
(43)2 eleven |
| (2)31 in |
(16)6 studies |
(30)2 10 |
(44)2 factors |
| (3)27 a |
(17)5 were |
(31)2 17 |
(45)2 key |
| (4)26 as |
(18)4 five |
(32)2 21 |
(46)2 knowledge |
| (5)22 and |
(19)4 practices |
(33)2 22 |
(47)2 many |
| (6)14 the |
(20)3 (a) |
(34)2 23 |
(48)2 more |
| (7)13 from |
(21)3 15 |
(35)2 26 |
(49)2 only |
| (8)10 through |
(22)3 28 |
(36)2 37 |
(50)2 peer-reviewed |
| (9)8 that |
(23)3 an |
(37)2 38 |
(51)2 proteins |
| (10)7 with |
(24)3 including |
(38)2 across |
(52)2 sPLA2-IIA |
| (11)6 by |
(25)3 to |
(39)2 among |
(53)2 significant |
| (12)6 for |
(26)3 using |
(40)2 barriers |
(54)2 three |
| (13)6 four |
(27)3 via |
(41)2 challenges |
|
| (14)6 of |
(28)3 which |
(42)2 during |
add keyword
--- WordNet output for identified ---