ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for important out of >500 occurrences
448856 occurrences (No.37 in the rank) during 5 years in the PubMed. [no cache] 500 found
12) We concluded that class I HDACs play an important role in bladder carcinogenesis through deregulation of proliferation, migration and apoptosis, constituting putative therapeutic targets.
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PMID:24293253 DOI:10.1002/mc.22117
2015 Molecular carcinogenesis
* Phenotypic impact of deregulated expression of class I histone deacetylases in urothelial cell carcinoma of the bladder.
- Deregulated expression of histone deacetylases (HDACs) has been implicated in tumorigenesis. Herein, we investigated class I HDACs expression in bladder urothelial cell carcinoma (BUCC), its prognostic value and biological significance. Significantly increased transcript levels of all HDACs were found in BUCC compared to 20 normal mucosas, and these were higher in lower grade and stage tumors. Increased HDAC3 levels were associated with improved patient survival. SiRNA experiments showed decrease cell viability and motility, and increased apoptosis. We concluded that class I HDACs play an important role in bladder carcinogenesis through deregulation of proliferation, migration and apoptosis, constituting putative therapeutic targets.
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(1)65 role (16)4 data (31)2 alternative (46)2 indicator
(2)37 for (17)4 differences (32)2 aspect (47)2 mechanism
(3)34 to (18)3 approach (33)2 baseline (48)2 model
(4)28 in (19)3 causes (34)2 because (49)2 molecular
(5)15 implications (20)3 clinical (35)2 bivalve, (50)2 not
(6)11 factor (21)3 findings (36)2 complication (51)2 pathogen
(7)9 *null* (22)3 genes (37)2 components (52)2 phenomenon
(8)9 and (23)3 health (38)2 consequences (53)2 physiological
(9)8 determinants (24)3 human (39)2 contributor (54)2 protective
(10)8 roles (25)3 insights (40)2 coping (55)2 route
(11)7 factors (26)3 policy (41)2 determinant (56)2 standard
(12)6 cause (27)3 predictors (42)2 economic (57)2 step
(13)5 component (28)3 public (43)2 element (58)2 strategic
(14)5 risk (29)3 when (44)2 fish (59)2 subset
(15)4 as (30)2 DNA (45)2 function (60)2 target

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--- WordNet output for important --- =>重要な, 有力な, 重大な, 大切な Overview of adj important The adj important has 5 senses (first 4 from tagged texts) 1. (146) important, of import -- (of great significance or value; "important people"; "the important questions of the day") 2. (4) significant, important -- (important in effect or meaning; "a significant change in tax laws"; "a significant change in the Constitution"; "a significant contribution"; "significant details"; "statistically significant") 3. (2) crucial, important -- (of extreme importance; vital to the resolution of a crisis; "a crucial moment in his career"; "a crucial election"; "a crucial issue for women") 4. (1) authoritative, important -- (having authority or ascendancy or influence; "an important official"; "the captain's authoritative manner") 5. important -- (having or suggesting a consciousness of high position; "recited the decree with an important air"; "took long important strides in the direction of his office") --- WordNet end ---