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- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for including out of >500 occurrences
468001 occurrences (No.36 in the rank) during 5 years in the PubMed. [no cache] 500 found
205) Pharmacokinetic parameters including Cmax and AUC24 indicated bioequivalence of the ODMs and the conventional immediate release tablets.
--- ABSTRACT ---
PMID:24252109 DOI:10.3109/03639045.2013.858742
2015 Drug development and industrial pharmacy
* Organic-aqueous crossover coating process for the desmopressin orally disintegrating microparticles.
- The purpose of the present study was to prepare desmopressin orally disintegrating microparticles (ODMs) using organic-aqueous crossover coating process which featured an organic sub-coating followed by an aqueous active coating. Sucrose beads and hydroxypropyl cellulose (HPC) were used as inert cores and a coating material, respectively. Characterizations including size distribution analysis, in-vitro release studies and in-vitro disintegration studies were performed. A pharmacokinetic study of the ODMs was also conducted in eight beagle dogs. It was found that sucrose beads should be coated using organic solvents to preserve their original morphology. For the active coating, the aqueous coating solution should be used for drug stability. When sucrose beads were coated using organic-aqueous crossover coating process, double-layer ODMs with round shapes were produced with detectable impurities below limit of US Pharmacopeia. The median size of ODMs was 195.6 μm, which was considered small enough for a good mouthfeel. The ODMs dissolved in artificial saliva within 15 s because of hydrophilic materials including sucrose and HPC in the ODMs. Because of its fast-dissolving properties, 100% release of the drug was reached within 5 min. Pharmacokinetic parameters including Cmax and AUC24 indicated bioequivalence of the ODMs and the conventional immediate release tablets. Therefore, by using the organic-aqueous crossover coating process, double-layer ODMs were successively prepared with small size, round shapes and good drug stability.
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(1)55 the (10)3 all (20)2 an (29)2 lower
(2)28 13 (11)3 cell (21)2 angiogenesis, (30)2 lung
(3)11 a (12)3 our (22)2 appropriate (31)2 many
(4)7 those (13)3 reduced (23)2 autism (32)2 questions
(5)5 in (14)3 their (24)2 changes (33)2 studies
(6)5 its (15)3 three (25)2 depression, (34)2 topical
(7)4 2 (17)2 3 (26)2 improved (35)2 two
(8)4 both (18)2 37 (27)2 increased
(9)3 age, (19)2 activated (28)2 induction

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--- WordNet output for including --- =>含む Overview of verb include The verb include has 4 senses (first 4 from tagged texts) 1. (234) include -- (have as a part, be made up out of; "The list includes the names of many famous writers") 2. (32) include -- (consider as part of something; "I include you in the list of culprits") 3. (18) include -- (add as part of something else; put in as part of a set, group, or category; "We must include this chemical element in the group") 4. (8) admit, let in, include -- (allow participation in or the right to be part of; permit to exercise the rights, functions, and responsibilities of; "admit someone to the profession"; "She was admitted to the New Jersey Bar") --- WordNet end ---