* Metoprolol and diltiazem ameliorate ziprasidone-induced prolonged corrected QT interval in rats.
- Ziprasidone, an atypical antipsychotic agent, has been shown to increase the corrected QT (QTc) interval in some patients. The aim of this study was to reveal the effects of metoprolol and diltiazem on ziprasidone drug-induced prolonged QTc interval. A total of 24 rats were equally divided into the following four groups: the first group was used as the control and received 1 mL/kg saline; 3 mg/kg ziprasidone and saline were administered to the second group; 3 mg/kg ziprasidone and 1 mg/kg metoprolol were administered to the third group and 3 mg/kg ziprasidone and 2 mg/kg diltiazem were administered to the fourth group. Two hours following application of the drugs, the QTc was calculated by performing electrocardiography in derivation (D)I. The duration of QTc interval was compared among the four groups. The mean QTc intervals were significantly increased in the third and fourth groups compared with the second group (p < 0.0005 and p < 0.0001, respectively). The study demonstrated the effectiveness of metoprolol and diltiazem in the prevention of ziprasidone-induced elongation in the QTc interval. Both metoprolol and diltiazem may be considered in the prophylactic therapy of high-risk patients who are using ziprasidone.
=>大きくなる, を増す, 増大させる, 強まる, 増加, 増える, 増やす
Overview of noun increase
The noun increase has 5 senses (first 5 from tagged texts)
1. (49) addition, increase, gain -- (a quantity that is added; "there was an addition to property
taxes this year"; "they recorded the cattle's gain in weight over a period of weeks")
2. (21) increase -- (a change resulting in an increase; "the increase is scheduled for next month")
3. (7) increase, increment, growth -- (a process of becoming larger or longer or more numerous or
more important; "the increase in unemployment"; "the growth of population")
4. (3) increase, increment -- (the amount by which something increases; "they proposed an increase
of 15 percent in the fare")
5. (3) increase, step-up -- (the act of increasing something; "he gave me an increase in salary")
Overview of verb increase
The verb increase has 2 senses (first 2 from tagged texts)
1. (86) increase -- (become bigger or greater in amount; "The amount of work increased")
2. (61) increase -- (make bigger or more; "The boss finally increased her salary"; "The university
increased the number of students it admitted")
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