ELIZA

return kwic search for increased out of >500 occurrences
611425 occurrences (No.13 in the rank) during 5 years in the PubMed. [cache]

147) Notably, increased expression of multiple crystallins and chaperones that respond to cellular stress and have anti-apoptotic properties was identified in the MyD88-inhibited mice.

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PMID:34562309 DOI:10.1111/jcmm.16893

2021 Journal of cellular and molecular medicine

* Quantitative proteomic analysis after neuroprotective MyD88 inhibition in the retinal degeneration 10 mouse.

- Progressive photoreceptor death occurs in blinding diseases such as retinitis pigmentosa. Myeloid differentiation primary response protein 88 (MyD88) is a central adaptor protein for innate immune system Toll-like receptors (TLR) and induces cytokine secretion during retinal disease. We recently demonstrated that inhibiting MyD88 in mouse models of retinal degeneration led to increased photoreceptor survival, which was associated with altered cytokines and increased neuroprotective microglia. However, the identity of additional molecular changes associated with MyD88 inhibitor-induced neuroprotection is not known. In this study, we used isobaric tags for relative and absolute quantification (iTRAQ) labelling followed by LC-MS/MS for quantitative proteomic analysis on the rd10 mouse model of retinal degeneration to identify protein pathways changed by MyD88 inhibition. Quantitative proteomics using iTRAQ LC-MS/MS is a high-throughput method ideal for providing insight into molecular pathways during disease and experimental treatments. Forty-two proteins were differentially expressed in retinas from mice treated with MyD88 inhibitor compared with control. Notably, increased expression of multiple crystallins and chaperones that respond to cellular stress and have anti-apoptotic properties was identified in the MyD88-inhibited mice. These data suggest that inhibiting MyD88 enhances chaperone-mediated retinal protection pathways. Therefore, this study provides insight into molecular events contributing to photoreceptor protection from modulating inflammation.

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(1)53 risk	(17)4 significantly	(33)2 CYP2B6	(50)2 likelihood
(2)32 the	(18)4 survival	(34)2 DNA	(51)2 mental
(3)19 in	(19)3 and	(35)2 ROS	(52)2 neutrophil
(4)11 levels	(20)3 at	(36)2 T	(53)2 odds
(5)8 by	(21)3 during	(38)2 airway	(54)2 patients'
(6)8 over	(22)3 exposure	(39)2 appetite,	(55)2 placental
(7)6 null	(23)3 focus	(40)2 approximately	(56)2 probability
(8)6 awareness	(24)3 for	(41)2 body	(57)2 rate
(9)6 expression	(25)3 from	(42)2 cell	(58)2 research
(10)6 or	(26)3 mortality	(43)2 demands	(59)2 resolution
(11)5 after	(27)3 sensitivity	(44)2 depressive	(60)2 retropalatal
(12)5 use	(28)3 severity	(45)2 detection	(61)2 substantially
(13)4 incidence	(29)3 signal	(46)2 health	(62)2 their
(14)4 prevalence	(30)3 time	(47)2 intracranial	(63)2 total
(15)4 production	(31)3 to	(48)2 intratumoral	(64)2 uptake
(16)4 serum	(32)3 vaccine	(49)2 lifespan	(65)2 virus

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--- WordNet output for increased --- =>力の増加 Overview of verb increase The verb increase has 2 senses (first 2 from tagged texts) 1. (86) increase -- (become bigger or greater in amount; "The amount of work increased") 2. (61) increase -- (make bigger or more; "The boss finally increased her salary"; "The university increased the number of students it admitted") Overview of adj increased The adj increased has 1 sense (first 1 from tagged texts) 1. (30) increased -- (made greater in size or amount or degree) --- WordNet end ---