ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for low out of >500 occurrences
318584 occurrences (No.68 in the rank) during 5 years in the PubMed. [cache]
138) In the present study, we found that the expression levels of two epigenetic markers, histone H3K27 trimethylation (H3K27me3), was low but histone H3S10 phosphorylation (pH3Ser10) was high in human bladder cancer tissues, which showed opposite expression patterns in their normal counterparts.
--- ABSTRACT ---
PMID:24115089 DOI:10.1002/mc.22084
2015 Molecular carcinogenesis
* Emodin modulates epigenetic modifications and suppresses bladder carcinoma cell growth.
- The deregulation of epigenetics was involved in early and subsequent carcinogenic events. Reversing cancer epigenetics to restore a normal epigenetic condition could be a rational approach for cancer treatment and specialized prevention. In the present study, we found that the expression levels of two epigenetic markers, histone H3K27 trimethylation (H3K27me3), was low but histone H3S10 phosphorylation (pH3Ser10) was high in human bladder cancer tissues, which showed opposite expression patterns in their normal counterparts. Thus, we investigated whether a natural product, emodin, has the ability to reverse these two epigenetic modifications and inhibit bladder cancer cell growth. Emodin significantly inhibited the cell growth of four bladder cancer cell lines in a dose- and time-dependent manner. Emodin treatment did not induce specific cell cycle arrest, but it altered epigenetic modifications. Emodin treatment resulted in the suppression of pH3Ser10 and increased H3K27me3, contributing to gene silencing in bladder cancer cells. Microarray analysis demonstrated that oncogenic genes including fatty acid binding protein 4 (FABP4) and fibroblast growth factor binding protein 1 (HBP17), RGS4, tissue inhibitor of metalloproteinase 3 (TIMP3), WNT5b, URB, and collagen, type VIII, alpha 1 (COL8A1) responsible for proliferation, survival, inflammation, and carcinogenesis were significantly repressed by emodin. The ChIP assays also showed that emodin increased H3K27me3 but decreased pH3Ser10 modifications on the promoters of repressed genes, which indicate that emodin reverses the cancer epigenetics towards normal epigenetic situations. In conclusion, our work demonstrates the significant anti-neoplastic activity of emodin on bladder cancer cells and elucidates the novel mechanisms of emodin-mediated epigenetic modulation of target genes. Our study warrants further investigation of emodin as an effective therapeutic or preventive agent for bladder cancer.
--- ABSTRACT END ---
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[frequency of next (right) word to low]
(1)21 and (18)4 or (35)2 Chilean (52)2 energy
(2)19 laser (19)4 socioeconomic (36)2 HLB (53)2 families
(3)11 doses (20)3 Er:YAG (37)2 OAs (54)2 genetic
(4)11 levels (21)3 O2 (38)2 acculturation (55)2 group
(5)10 *null* (22)3 PFR (39)2 activities (56)2 maternal
(6)10 cost (23)3 PbB (40)2 activity (57)2 method
(7)10 lipoprotein (24)3 STT (41)2 after (58)2 molecular
(8)8 back (25)3 concentrations (42)2 areas (59)2 oral
(9)8 birth (26)3 educational (43)2 at (60)2 pH
(10)8 dose (27)3 features (44)2 bioavailability (61)2 peer
(11)7 in (28)3 risk (45)2 body (62)2 population
(12)7 level (29)3 serum (46)2 cancer (63)2 radiation
(13)6 birthweight (30)3 shear (47)2 children (64)2 resilience
(14)5 but (31)3 tumours (48)2 coverage (65)2 running
(15)4 as (32)3 vagal (49)2 degree (66)2 sensitivity
(16)4 carbon (33)3 water (50)2 density (67)2 settings
(17)4 income (34)3 whole-body (51)2 education (68)2 temperature

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--- WordNet output for low --- =>安い, 低いところ, 卑劣に, 粗食で, 低い(もの), 弱い, 粗末な, 乏しい, 衿ぐりが深い, 建物の低い, 下劣な, 低級な Overview of noun low The noun low has 4 senses (no senses from tagged texts) 1. low, depression -- (an air mass of lower pressure; often brings precipitation; "a low moved in over night bringing sleet and snow") 2. Low, David Low, Sir David Low, Sir David Alexander Cecil Low -- (British political cartoonist (born in New Zealand) who created the character Colonel Blimp (1891-1963)) 3. low -- (a low level or position or degree; "the stock market fell to a new low") 4. first gear, first, low gear, low -- (the lowest forward gear ratio in the gear box of a motor vehicle; used to start a car moving) Overview of verb low The verb low has 1 sense (no senses from tagged texts) 1. moo, low -- (make a low noise, characteristic of bovines) Overview of adj low The adj low has 10 senses (first 6 from tagged texts) 1. (55) low -- (less than normal in degree or intensity or amount; "low prices"; "the reservoir is low") 2. (23) low -- (literal meanings; being at or having a relatively small elevation or upward extension; "low ceilings"; "low clouds"; "low hills"; "the sun is low"; "low furniture"; "a low bow") 3. (11) low, low-toned -- (very low in volume; "a low murmur"; "the low-toned murmur of the surf") 4. (6) low -- (unrefined in character; "low comedy") 5. (4) low, low-pitched -- (used of sounds and voices; low in pitch or frequency) 6. (3) abject, low, low-down, miserable, scummy, scurvy -- (of the most contemptible kind; "abject cowardice"; "a low stunt to pull"; "a low-down sneak"; "his miserable treatment of his family"; "You miserable skunk!"; "a scummy rabble"; "a scurvy trick") 7. humble, low, lowly, modest, small -- (low or inferior in station or quality; "a humble cottage"; "a lowly parish priest"; "a modest man of the people"; "small beginnings") 8. depleted, low -- (no longer sufficient; "supplies are low"; "our funds are depleted") 9. broken, crushed, humbled, humiliated, low -- (subdued or brought low in condition or status; "brought low"; "a broken man"; "his broken spirit") 10. gloomy, grim, blue, depressed, dispirited, down, downcast, downhearted, down in the mouth, low, low-spirited -- (filled with melancholy and despondency ; "gloomy at the thought of what he had to face"; "gloomy predictions"; "a gloomy silence"; "took a grim view of the economy"; "the darkening mood"; "lonely and blue in a strange city"; "depressed by the loss of his job"; "a dispirited and resigned expression on her face"; "downcast after his defeat"; "feeling discouraged and downhearted") Overview of adv low The adv low has 1 sense (first 1 from tagged texts) 1. (3) low -- (in a low position; near the ground; "the branches hung low") --- WordNet end ---