ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for low out of >500 occurrences
318584 occurrences (No.68 in the rank) during 5 years in the PubMed. [no cache] 500 found
225) Famotidine HCl has low bioavailability (40-45%) due to its narrow absorption window and low solubility in intestinal pH.
--- ABSTRACT ---
PMID:24350634 DOI:10.3109/10717544.2013.868960
2015 Drug delivery
* Design and development of novel lipid based gastroretentive delivery system: response surface analysis, in-vivo imaging and pharmacokinetic study.
- Famotidine HCl has low bioavailability (40-45%) due to its narrow absorption window and low solubility in intestinal pH. Lipids were utilized in the formulation of novel gastroretentive dosage forms to increase the availability of famotidine HCl at its absorption site. Novel non-swellable gastroretentive lipid disks (D) and swellable compression coated tablets with a lipid core (T) were prepared. Formulae were characterized by friability testing, in-vitro buoyancy, in-vitro drug release and scanning electron microscopy (SEM). Factorial designs of 2(2 )× 3(1) and 3(2) were planned for the optimization of disks and tablets, respectively, using Design-Expert® software. X-ray imaging was used for the in-vivo visualization of the selected formula in human gastrointestinal tract (GIT). Moreover, a bioavailability study was performed in healthy human volunteers using the optimized disk formula (D10). Results showed that formulae D10 (containing stearyl alcohol and polyethylene glycol in a ratio of 9:1 w/w) and T7 (containing polyethylene oxide only) had highest desirability values (0.684 and 0.842, respectively). Lipids achieved instantaneous floating and sustained the release of famotidine HCl over a prolonged period of time with significant bioavailability enhancement.
--- ABSTRACT END ---
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[frequency of next (right) word to low]
(1)21 and (18)4 or (35)2 Chilean (52)2 energy
(2)19 laser (19)4 socioeconomic (36)2 HLB (53)2 families
(3)11 doses (20)3 Er:YAG (37)2 OAs (54)2 genetic
(4)11 levels (21)3 O2 (38)2 acculturation (55)2 group
(5)10 *null* (22)3 PFR (39)2 activities (56)2 maternal
(6)10 cost (23)3 PbB (40)2 activity (57)2 method
(7)10 lipoprotein (24)3 STT (41)2 after (58)2 molecular
(8)8 back (25)3 concentrations (42)2 areas (59)2 oral
(9)8 birth (26)3 educational (43)2 at (60)2 pH
(10)8 dose (27)3 features (44)2 bioavailability (61)2 peer
(11)7 in (28)3 risk (45)2 body (62)2 population
(12)7 level (29)3 serum (46)2 cancer (63)2 radiation
(13)6 birthweight (30)3 shear (47)2 children (64)2 resilience
(14)5 but (31)3 tumours (48)2 coverage (65)2 running
(15)4 as (32)3 vagal (49)2 degree (66)2 sensitivity
(16)4 carbon (33)3 water (50)2 density (67)2 settings
(17)4 income (34)3 whole-body (51)2 education (68)2 temperature

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--- WordNet output for low --- =>安い, 低いところ, 卑劣に, 粗食で, 低い(もの), 弱い, 粗末な, 乏しい, 衿ぐりが深い, 建物の低い, 下劣な, 低級な Overview of noun low The noun low has 4 senses (no senses from tagged texts) 1. low, depression -- (an air mass of lower pressure; often brings precipitation; "a low moved in over night bringing sleet and snow") 2. Low, David Low, Sir David Low, Sir David Alexander Cecil Low -- (British political cartoonist (born in New Zealand) who created the character Colonel Blimp (1891-1963)) 3. low -- (a low level or position or degree; "the stock market fell to a new low") 4. first gear, first, low gear, low -- (the lowest forward gear ratio in the gear box of a motor vehicle; used to start a car moving) Overview of verb low The verb low has 1 sense (no senses from tagged texts) 1. moo, low -- (make a low noise, characteristic of bovines) Overview of adj low The adj low has 10 senses (first 6 from tagged texts) 1. (55) low -- (less than normal in degree or intensity or amount; "low prices"; "the reservoir is low") 2. (23) low -- (literal meanings; being at or having a relatively small elevation or upward extension; "low ceilings"; "low clouds"; "low hills"; "the sun is low"; "low furniture"; "a low bow") 3. (11) low, low-toned -- (very low in volume; "a low murmur"; "the low-toned murmur of the surf") 4. (6) low -- (unrefined in character; "low comedy") 5. (4) low, low-pitched -- (used of sounds and voices; low in pitch or frequency) 6. (3) abject, low, low-down, miserable, scummy, scurvy -- (of the most contemptible kind; "abject cowardice"; "a low stunt to pull"; "a low-down sneak"; "his miserable treatment of his family"; "You miserable skunk!"; "a scummy rabble"; "a scurvy trick") 7. humble, low, lowly, modest, small -- (low or inferior in station or quality; "a humble cottage"; "a lowly parish priest"; "a modest man of the people"; "small beginnings") 8. depleted, low -- (no longer sufficient; "supplies are low"; "our funds are depleted") 9. broken, crushed, humbled, humiliated, low -- (subdued or brought low in condition or status; "brought low"; "a broken man"; "his broken spirit") 10. gloomy, grim, blue, depressed, dispirited, down, downcast, downhearted, down in the mouth, low, low-spirited -- (filled with melancholy and despondency ; "gloomy at the thought of what he had to face"; "gloomy predictions"; "a gloomy silence"; "took a grim view of the economy"; "the darkening mood"; "lonely and blue in a strange city"; "depressed by the loss of his job"; "a dispirited and resigned expression on her face"; "downcast after his defeat"; "feeling discouraged and downhearted") Overview of adv low The adv low has 1 sense (first 1 from tagged texts) 1. (3) low -- (in a low position; near the ground; "the branches hung low") --- WordNet end ---