* Formulation of nanoemulsion: a comparison between phase inversion composition method and high-pressure homogenization method.
- There is lot of confusion in the literatures regarding the method of production of nanoemulsion. According to some authors, only the methods using high energy like high-pressure microfluidizer or high-frequency ultra-sonic devices can produce actual nanoemulsions. In contrast to this concept, one research group reported for the first time the preparation of nanoemulsion by a low-energy method. Later on many authors reported about the low-energy emulsification method. The purpose of this work is to formulate, evaluate and compare nanoemulsions prepared using high-energy as well as low-energy method. Nanoemulsions formulated were based on the phase inversion composition technique (low energy method) and were selected from the ternary phase diagram based on the criterion of their being a minimum concentration of S(mix) used in the formulation. For high-pressure homogenization method (high energy method) Design-Expert software was used, and the desirability function was probed to acquire an optimized formulation. No significant difference (p > 0.05) was observed in the globule size of formulations made by each method, but the value of poly-dispersibility index between the two methods was found to be extremely significant (p < 0.001). A very significant difference (p < 0.001) was observed in the drug release from formulations made by each method. More than 60% of the drug was released from all the formulations in the initial 2 h of the dissolution study.
=>安い, 低いところ, 卑劣に, 粗食で, 低い(もの), 弱い, 粗末な, 乏しい, 衿ぐりが深い, 建物の低い,
下劣な, 低級な
Overview of noun low
The noun low has 4 senses (no senses from tagged texts)
1. low, depression -- (an air mass of lower pressure; often brings precipitation; "a low moved in
over night bringing sleet and snow")
2. Low, David Low, Sir David Low, Sir David Alexander Cecil Low -- (British political cartoonist
(born in New Zealand) who created the character Colonel Blimp (1891-1963))
3. low -- (a low level or position or degree; "the stock market fell to a new low")
4. first gear, first, low gear, low -- (the lowest forward gear ratio in the gear box of a motor
vehicle; used to start a car moving)
Overview of verb low
The verb low has 1 sense (no senses from tagged texts)
1. moo, low -- (make a low noise, characteristic of bovines)
Overview of adj low
The adj low has 10 senses (first 6 from tagged texts)
1. (55) low -- (less than normal in degree or intensity or amount; "low prices"; "the reservoir is
low")
2. (23) low -- (literal meanings; being at or having a relatively small elevation or upward
extension; "low ceilings"; "low clouds"; "low hills"; "the sun is low"; "low furniture"; "a low
bow")
3. (11) low, low-toned -- (very low in volume; "a low murmur"; "the low-toned murmur of the surf")
4. (6) low -- (unrefined in character; "low comedy")
5. (4) low, low-pitched -- (used of sounds and voices; low in pitch or frequency)
6. (3) abject, low, low-down, miserable, scummy, scurvy -- (of the most contemptible kind; "abject
cowardice"; "a low stunt to pull"; "a low-down sneak"; "his miserable treatment of his family"; "You
miserable skunk!"; "a scummy rabble"; "a scurvy trick")
7. humble, low, lowly, modest, small -- (low or inferior in station or quality; "a humble cottage";
"a lowly parish priest"; "a modest man of the people"; "small beginnings")
8. depleted, low -- (no longer sufficient; "supplies are low"; "our funds are depleted")
9. broken, crushed, humbled, humiliated, low -- (subdued or brought low in condition or status;
"brought low"; "a broken man"; "his broken spirit")
10. gloomy, grim, blue, depressed, dispirited, down, downcast, downhearted, down in the mouth, low,
low-spirited -- (filled with melancholy and despondency ; "gloomy at the thought of what he had to
face"; "gloomy predictions"; "a gloomy silence"; "took a grim view of the economy"; "the darkening
mood"; "lonely and blue in a strange city"; "depressed by the loss of his job"; "a dispirited and
resigned expression on her face"; "downcast after his defeat"; "feeling discouraged and
downhearted")
Overview of adv low
The adv low has 1 sense (first 1 from tagged texts)
1. (3) low -- (in a low position; near the ground; "the branches hung low")
--- WordNet end ---