* The toxicity, transport and uptake of nanoparticles in the in vitro BeWo b30 placental cell barrier model used within NanoTEST.
- Despite the rapid ongoing expansion in the use of nanomaterials, we still know little about their biological interaction and biodistribution within the human body. If medically relevant nanoparticles can cross specific cell barriers they may disseminate through the body beyond the original target and may reach particularly sensitive areas such as the foetus. This study utilised an in vitro barrier model of the placenta to explore toxicity, uptake and transport of iron oxide and silica nanoparticles. The findings indicate that these nanoparticles can transfer extensively across the placental barrier model but physico-chemical characteristics such as surface chemistry impact upon both uptake and transport. Iron oxide cytotoxicity was evident at lower doses and shorter exposure compared with silica and may be of clinical relevance. In vivo correlation of in vitro findings is essential but in vitro models may provide worst case-exposure estimates to help reduce the amount of testing required.
=>1.低くする/なる, 下げる/下がる, 卑しめる, 2.しかめっ面, 3.lowの比較級
Overview of noun lower
The noun lower has 1 sense (no senses from tagged texts)
1. lower berth, lower -- (the lower of two berths)
Overview of verb lower
The verb lower has 5 senses (first 3 from tagged texts)
1. (15) lower, take down, let down, get down, bring down -- (move something or somebody to a lower
position; "take down the vase from the shelf")
2. (6) lower, lour -- (set lower; "lower a rating"; "lower expectations")
3. (1) turn down, lower, lour -- (make lower or quieter; "turn down the volume of a radio")
4. lower, depress -- (cause to drop or sink; "The lack of rain had depressed the water level in the
reservoir")
5. frown, glower, lour, lower -- (look angry or sullen, wrinkle one's forehead, as if to signal
disapproval)
Overview of adj low
The adj low has 10 senses (first 6 from tagged texts)
1. (55) low -- (less than normal in degree or intensity or amount; "low prices"; "the reservoir is
low")
2. (23) low -- (literal meanings; being at or having a relatively small elevation or upward
extension; "low ceilings"; "low clouds"; "low hills"; "the sun is low"; "low furniture"; "a low
bow")
3. (11) low, low-toned -- (very low in volume; "a low murmur"; "the low-toned murmur of the surf")
4. (6) low -- (unrefined in character; "low comedy")
5. (4) low, low-pitched -- (used of sounds and voices; low in pitch or frequency)
6. (3) abject, low, low-down, miserable, scummy, scurvy -- (of the most contemptible kind; "abject
cowardice"; "a low stunt to pull"; "a low-down sneak"; "his miserable treatment of his family"; "You
miserable skunk!"; "a scummy rabble"; "a scurvy trick")
7. humble, low, lowly, modest, small -- (low or inferior in station or quality; "a humble cottage";
"a lowly parish priest"; "a modest man of the people"; "small beginnings")
8. depleted, low -- (no longer sufficient; "supplies are low"; "our funds are depleted")
9. broken, crushed, humbled, humiliated, low -- (subdued or brought low in condition or status;
"brought low"; "a broken man"; "his broken spirit")
10. gloomy, grim, blue, depressed, dispirited, down, downcast, downhearted, down in the mouth, low,
low-spirited -- (filled with melancholy and despondency ; "gloomy at the thought of what he had to
face"; "gloomy predictions"; "a gloomy silence"; "took a grim view of the economy"; "the darkening
mood"; "lonely and blue in a strange city"; "depressed by the loss of his job"; "a dispirited and
resigned expression on her face"; "downcast after his defeat"; "feeling discouraged and
downhearted")
--- WordNet end ---