ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for model out of >500 occurrences
469466 occurrences (No.35 in the rank) during 5 years in the PubMed. [no cache] 500 found
12) A finite element model of a single cell was created and used to compute the biophysical stimuli generated within a cell under mechanical loading.
--- ABSTRACT ---
PMID:23947334 DOI:10.1080/10255842.2013.811234
2015 Computer methods in biomechanics and biomedical engineering
* Effect of membrane stiffness and cytoskeletal element density on mechanical stimuli within cells: an analysis of the consequences of ageing in cells.
- A finite element model of a single cell was created and used to compute the biophysical stimuli generated within a cell under mechanical loading. Major cellular components were incorporated in the model: the membrane, cytoplasm, nucleus, microtubules, actin filaments, intermediate filaments, nuclear lamina and chromatin. The model used multiple sets of tensegrity structures. Viscoelastic properties were assigned to the continuum components. To corroborate the model, a simulation of atomic force microscopy indentation was performed and results showed a force/indentation simulation with the range of experimental results. A parametric analysis of both increasing membrane stiffness (thereby modelling membrane peroxidation with age) and decreasing density of cytoskeletal elements (thereby modelling reduced actin density with age) was performed. Comparing normal and aged cells under indentation predicts that aged cells have a lower membrane area subjected to high strain as compared with young cells, but the difference, surprisingly, is very small and may not be measurable experimentally. Ageing is predicted to have a more significant effect on strain deep in the nucleus. These results show that computation of biophysical stimuli within cells are achievable with single-cell computational models; correspondence between computed and measured force/displacement behaviours provides a high-level validation of the model. Regarding the effect of ageing, the models suggest only small, although possibly physiologically significant, differences in internal biophysical stimuli between normal and aged cells.
--- ABSTRACT END ---
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[frequency of next (right) word to model]
(1)63 of (12)7 as (23)3 assessment (34)2 demonstrated
(2)55 *null* (13)6 are (24)3 fit (35)2 it
(3)35 for (14)6 system (25)3 revealed (36)2 joints
(4)28 was (15)5 a (26)3 showed (37)2 may
(5)26 to (16)5 selection (27)3 systems (38)2 not
(6)16 and (17)5 which (28)3 were (39)2 results
(7)16 in (18)5 will (29)2 allows (40)2 species
(8)16 is (19)4 can (30)2 analyses (41)2 such
(9)16 with (20)4 parameters (31)2 appropriate (42)2 used
(10)12 that (21)4 using (32)2 biological
(11)8 the (22)4 we (33)2 consists

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--- WordNet output for model --- =>模型, 作る, 形に表わす, 模範, モデル, 型, 模型の, 模範となる, かたどる, 手本, モデルをする, 手本となる Overview of noun model The noun model has 9 senses (first 7 from tagged texts) 1. (19) model, theoretical account, framework -- (a hypothetical description of a complex entity or process; "the computer program was based on a model of the circulatory and respiratory systems") 2. (11) model -- (a type of product; "his car was an old model") 3. (6) model, poser -- (a person who poses for a photographer or painter or sculptor; "the president didn't have time to be a model so the artist worked from photos") 4. (4) model, simulation -- (representation of something (sometimes on a smaller scale)) 5. (3) exemplar, example, model, good example -- (something to be imitated; "an exemplar of success"; "a model of clarity"; "he is the very model of a modern major general") 6. (1) model, role model -- (someone worthy of imitation; "every child needs a role model") 7. (1) model, example -- (a representative form or pattern; "I profited from his example") 8. mannequin, manikin, mannikin, manakin, fashion model, model -- (a woman who wears clothes to display fashions; "she was too fat to be a mannequin") 9. model, modelling, modeling -- (the act of representing something (usually on a smaller scale)) Overview of verb model The verb model has 6 senses (first 2 from tagged texts) 1. (1) model, pattern -- (plan or create according to a model or models) 2. (1) model, mold, mould -- (form in clay, wax, etc; "model a head with clay") 3. model, pose, sit, posture -- (assume a posture as for artistic purposes; "We don't know the woman who posed for Leonardo so often") 4. model -- (display (clothes) as a mannequin; "model the latest fashion") 5. model, simulate -- (create a representation or model of; "The pilots are trained in conditions simulating high-altitude flights") 6. model, mock up -- (construct a model of; "model an airplane") Overview of adj model The adj model has 1 sense (first 1 from tagged texts) 1. (1) exemplary, model -- (worthy of imitation; "exemplary behavior"; "model citizens") --- WordNet end ---