* Endosialidases: Versatile Tools for the Study of Polysialic Acid.
- Polysialic acid is an α2,8-linked N-acetylneuraminic acid polymer found on the surface of both bacterial and eukaryotic cells. Endosialidases are bacteriophage-borne glycosyl hydrolases that specifically cleave polysialic acid. The crystal structure of an endosialidase reveals a trimeric mushroom-shaped molecule which, in addition to the active site, harbors two additional polysialic acid binding sites. Folding of the protein crucially depends on an intramolecular C-terminal chaperone domain that is proteolytically released in an intramolecular reaction. Based on structural data and previous considerations, an updated catalytic mechanism is discussed. Endosialidases degrade polysialic acid in a processive mode of action, and a model for its mechanism is suggested. The review summarizes the structural and biochemical elucidations of the last decade and the importance of endosialidases in biochemical and medical applications. Active endosialidases are important tools in studies on the biological roles of polysialic acid, such as the pathogenesis of septicemia and meningitis by polysialic acid-encapsulated bacteria, or its role as a modulator of the adhesion and interactions of neural and other cells. Endosialidase mutants that have lost their polysialic acid cleaving activity while retaining their polysialic acid binding capability have been fused to green fluorescent protein to provide an efficient tool for the specific detection of polysialic acid.
=>模型, 作る, 形に表わす, 模範, モデル, 型, 模型の, 模範となる, かたどる, 手本, モデルをする,
手本となる
Overview of noun model
The noun model has 9 senses (first 7 from tagged texts)
1. (19) model, theoretical account, framework -- (a hypothetical description of a complex entity or
process; "the computer program was based on a model of the circulatory and respiratory systems")
2. (11) model -- (a type of product; "his car was an old model")
3. (6) model, poser -- (a person who poses for a photographer or painter or sculptor; "the president
didn't have time to be a model so the artist worked from photos")
4. (4) model, simulation -- (representation of something (sometimes on a smaller scale))
5. (3) exemplar, example, model, good example -- (something to be imitated; "an exemplar of
success"; "a model of clarity"; "he is the very model of a modern major general")
6. (1) model, role model -- (someone worthy of imitation; "every child needs a role model")
7. (1) model, example -- (a representative form or pattern; "I profited from his example")
8. mannequin, manikin, mannikin, manakin, fashion model, model -- (a woman who wears clothes to
display fashions; "she was too fat to be a mannequin")
9. model, modelling, modeling -- (the act of representing something (usually on a smaller scale))
Overview of verb model
The verb model has 6 senses (first 2 from tagged texts)
1. (1) model, pattern -- (plan or create according to a model or models)
2. (1) model, mold, mould -- (form in clay, wax, etc; "model a head with clay")
3. model, pose, sit, posture -- (assume a posture as for artistic purposes; "We don't know the woman
who posed for Leonardo so often")
4. model -- (display (clothes) as a mannequin; "model the latest fashion")
5. model, simulate -- (create a representation or model of; "The pilots are trained in conditions
simulating high-altitude flights")
6. model, mock up -- (construct a model of; "model an airplane")
Overview of adj model
The adj model has 1 sense (first 1 from tagged texts)
1. (1) exemplary, model -- (worthy of imitation; "exemplary behavior"; "model citizens")
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