ELIZA

return kwic search for model out of >500 occurrences
469466 occurrences (No.35 in the rank) during 5 years in the PubMed. [no cache] 500 found

267) Biologically important findings are reported, and these findings also suggest that it is very important to assume a model with skew distribution in order to achieve reliable results, in particular, when the data exhibit skewness.

--- ABSTRACT ---

PMID:22045781 DOI:10.1177/0962280211426184

2015 Statistical methods in medical research

* Piecewise mixed-effects models with skew distributions for evaluating viral load changes: A Bayesian approach.

- Studies of human immunodeficiency virus dynamics in acquired immuno deficiency syndrome (AIDS) research are very important in evaluating the effectiveness of antiretroviral (ARV) therapies. The potency of ARV agents in AIDS clinical trials can be assessed on the basis of a viral response such as viral decay rate or viral load change in plasma. Following ARV treatment, the profile of each subject's viral load tends to follow a 'broken stick'-like dynamic trajectory, indicating multiple phases of decline and increase in viral loads. Such multiple-phases (change-points) can be described by a random change-point model with random subject-specific parameters. One usually assumes a normal distribution for model error. However, this assumption may be unrealistic, obscuring important features of within- and among-subject variations. In this article, we propose piecewise linear mixed-effects models with skew-elliptical distributions to describe the time trend of a response variable under a Bayesian framework. This methodology can be widely applied to real problems for longitudinal studies. A real data analysis, using viral load data from an AIDS study, is carried out to illustrate the proposed method by comparing various candidate models. Biologically important findings are reported, and these findings also suggest that it is very important to assume a model with skew distribution in order to achieve reliable results, in particular, when the data exhibit skewness.

--- ABSTRACT END ---

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[frequency of next (right) word to model]

(1)63 of	(12)7 as	(23)3 assessment	(34)2 demonstrated
(2)55 null	(13)6 are	(24)3 fit	(35)2 it
(3)35 for	(14)6 system	(25)3 revealed	(36)2 joints
(4)28 was	(15)5 a	(26)3 showed	(37)2 may
(5)26 to	(16)5 selection	(27)3 systems	(38)2 not
(6)16 and	(17)5 which	(28)3 were	(39)2 results
(7)16 in	(18)5 will	(29)2 allows	(40)2 species
(8)16 is	(19)4 can	(30)2 analyses	(41)2 such
(9)16 with	(20)4 parameters	(31)2 appropriate	(42)2 used
(10)12 that	(21)4 using	(32)2 biological
(11)8 the	(22)4 we	(33)2 consists

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--- WordNet output for model --- =>模型, 作る, 形に表わす, 模範, モデル, 型, 模型の, 模範となる, かたどる, 手本, モデルをする, 手本となる Overview of noun model The noun model has 9 senses (first 7 from tagged texts) 1. (19) model, theoretical account, framework -- (a hypothetical description of a complex entity or process; "the computer program was based on a model of the circulatory and respiratory systems") 2. (11) model -- (a type of product; "his car was an old model") 3. (6) model, poser -- (a person who poses for a photographer or painter or sculptor; "the president didn't have time to be a model so the artist worked from photos") 4. (4) model, simulation -- (representation of something (sometimes on a smaller scale)) 5. (3) exemplar, example, model, good example -- (something to be imitated; "an exemplar of success"; "a model of clarity"; "he is the very model of a modern major general") 6. (1) model, role model -- (someone worthy of imitation; "every child needs a role model") 7. (1) model, example -- (a representative form or pattern; "I profited from his example") 8. mannequin, manikin, mannikin, manakin, fashion model, model -- (a woman who wears clothes to display fashions; "she was too fat to be a mannequin") 9. model, modelling, modeling -- (the act of representing something (usually on a smaller scale)) Overview of verb model The verb model has 6 senses (first 2 from tagged texts) 1. (1) model, pattern -- (plan or create according to a model or models) 2. (1) model, mold, mould -- (form in clay, wax, etc; "model a head with clay") 3. model, pose, sit, posture -- (assume a posture as for artistic purposes; "We don't know the woman who posed for Leonardo so often") 4. model -- (display (clothes) as a mannequin; "model the latest fashion") 5. model, simulate -- (create a representation or model of; "The pilots are trained in conditions simulating high-altitude flights") 6. model, mock up -- (construct a model of; "model an airplane") Overview of adj model The adj model has 1 sense (first 1 from tagged texts) 1. (1) exemplary, model -- (worthy of imitation; "exemplary behavior"; "model citizens") --- WordNet end ---