ELIZA

return kwic search for molecular out of >500 occurrences
333489 occurrences (No.56 in the rank) during 5 years in the PubMed. [cache]

111) We have investigated the pharmacology using isogenic cancer cell screening, cellular profiling, and complementary phenotypic assays, and unveiled the underlying molecular mechanism by in vitro biochemical studies and high-resolution structural determination of the α/β-tubulin-GB1 complex.

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PMID:33619102 DOI:10.1073/pnas.2021847118

2021 Proceedings of the National Academy of Sciences of the United States of America

* Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site.

- Tubulin-targeted chemotherapy has proven to be a successful and wide spectrum strategy against solid and liquid malignancies. Therefore, new ways to modulate this essential protein could lead to new antitumoral pharmacological approaches. Currently known tubulin agents bind to six distinct sites at α/β-tubulin either promoting microtubule stabilization or depolymerization. We have discovered a seventh binding site at the tubulin intradimer interface where a novel microtubule-destabilizing cyclodepsipeptide, termed gatorbulin-1 (GB1), binds. GB1 has a unique chemotype produced by a marine cyanobacterium. We have elucidated this dual, chemical and mechanistic, novelty through multidimensional characterization, starting with bioactivity-guided natural product isolation and multinuclei NMR-based structure determination, revealing the modified pentapeptide with a functionally critical hydroxamate group; and validation by total synthesis. We have investigated the pharmacology using isogenic cancer cell screening, cellular profiling, and complementary phenotypic assays, and unveiled the underlying molecular mechanism by in vitro biochemical studies and high-resolution structural determination of the α/β-tubulin-GB1 complex.

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(1)65 mechanisms	(19)4 analysis	(37)3 pharmacological	(55)2 measurements
(2)25 dynamics	(20)4 level,	(38)3 profiling	(56)2 medicine
(3)20 and	(21)4 modeling	(39)3 recognition	(57)2 methods
(4)14 mechanism	(22)4 processes	(40)3 response	(58)2 monitoring
(5)13 docking	(23)4 properties	(41)2 actions	(59)2 pathways,
(6)12 basis	(24)4 testing	(42)2 biological	(60)2 rotational
(7)11 pathways	(25)3 cellular,	(43)2 characterisation	(61)2 signaling
(8)8 details	(26)3 characteristics	(44)2 clock	(62)2 signals
(9)7 level	(27)3 clock,	(45)2 crowding	(63)2 signature
(10)7 markers	(28)3 composition	(46)2 data	(64)2 signatures
(11)7 patterns	(29)3 diagnoses	(47)2 determinant	(65)2 subtype
(12)7 weight	(30)3 effects	(48)2 diagnosis	(66)2 supporting
(13)6 subtypes	(31)3 features	(49)2 distributions	(67)2 target
(14)6 targets	(32)3 genetic	(50)2 docking,	(68)2 to
(15)5 changes	(33)3 imaging	(51)2 efficacy	(69)2 trajectory
(16)5 characterization	(34)3 initiating	(52)2 genetic,
(17)5 determinants	(35)3 mechanism,	(53)2 identity
(18)5 events	(36)3 pathology	(54)2 investigations

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--- WordNet output for molecular --- =>分子の Overview of adj molecular The adj molecular has 2 senses (first 1 from tagged texts) 1. (6) molecular -- (relating to or produced by or consisting of molecules; "molecular structure"; "molecular oxygen"; "molecular weight is the sum of all the atoms in a molecule") 2. molecular -- (relating to simple or elementary organization; "proceed by more and more detailed analysis to the molecular facts of perception"--G.A. Miller) --- WordNet end ---