* Unusual genetic aberrations including a deletion of KLF6 tumor suppressor gene revealed by integrated cytogenetic approaches in a pediatric ewing sarcoma.
- Ewing sarcoma is the third most common sarcoma in children and young adults. Its characteristic chromosomal rearrangement results in a chimerical EWSR1-ETS transcription factor. Secondary genetic alterations are very common. Membranous expression of CD99 is seen in almost all tumors. We report 2 unusual cytogenetic findings in a pediatric Ewing sarcoma, an insertion of the MIC2 gene encoding CD99 from Xp to 10p and a submicroscopic deletion of the well-known tumor supressor gene KLF6. The latter has not been described previously in pediatric neoplasms. Molecular pathways in tumorigenesis and genetic complexity in cancer are discussed.
=>分子の
Overview of adj molecular
The adj molecular has 2 senses (first 1 from tagged texts)
1. (6) molecular -- (relating to or produced by or consisting of molecules; "molecular structure";
"molecular oxygen"; "molecular weight is the sum of all the atoms in a molecule")
2. molecular -- (relating to simple or elementary organization; "proceed by more and more detailed
analysis to the molecular facts of perception"--G.A. Miller)
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