ELIZA

return kwic search for molecular out of >500 occurrences
333489 occurrences (No.56 in the rank) during 5 years in the PubMed. [cache]

54) This review focuses on molecular mechanisms underlying the sex-differences of CVD in aging.

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PMID:35822017 DOI:10.3389/fragi.2021.725884

2021 Frontiers in aging

* Sex Differences in Molecular Mechanisms of Cardiovascular Aging.

- Cardiovascular disease (CVD) is still the leading cause of illness and death in the Western world. Cardiovascular aging is a progressive modification occurring in cardiac and vascular morphology and physiology where increased endothelial dysfunction and arterial stiffness are observed, generally accompanied by increased systolic blood pressure and augmented pulse pressure. The effects of biological sex on cardiovascular pathophysiology have long been known. The incidence of hypertension is higher in men, and it increases in postmenopausal women. Premenopausal women are protected from CVD compared with age-matched men and this protective effect is lost with menopause, suggesting that sex-hormones influence blood pressure regulation. In parallel, the heart progressively remodels over the course of life and the pattern of cardiac remodeling also differs between the sexes. Lower autonomic tone, reduced baroreceptor response, and greater vascular function are observed in premenopausal women than men of similar age. However, postmenopausal women have stiffer arteries than their male counterparts. The biological mechanisms responsible for sex-related differences observed in cardiovascular aging are being unraveled over the last several decades. This review focuses on molecular mechanisms underlying the sex-differences of CVD in aging.

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[frequency of next (right) word to molecular]

(1)65 mechanisms	(19)4 analysis	(37)3 pharmacological	(55)2 measurements
(2)25 dynamics	(20)4 level,	(38)3 profiling	(56)2 medicine
(3)20 and	(21)4 modeling	(39)3 recognition	(57)2 methods
(4)14 mechanism	(22)4 processes	(40)3 response	(58)2 monitoring
(5)13 docking	(23)4 properties	(41)2 actions	(59)2 pathways,
(6)12 basis	(24)4 testing	(42)2 biological	(60)2 rotational
(7)11 pathways	(25)3 cellular,	(43)2 characterisation	(61)2 signaling
(8)8 details	(26)3 characteristics	(44)2 clock	(62)2 signals
(9)7 level	(27)3 clock,	(45)2 crowding	(63)2 signature
(10)7 markers	(28)3 composition	(46)2 data	(64)2 signatures
(11)7 patterns	(29)3 diagnoses	(47)2 determinant	(65)2 subtype
(12)7 weight	(30)3 effects	(48)2 diagnosis	(66)2 supporting
(13)6 subtypes	(31)3 features	(49)2 distributions	(67)2 target
(14)6 targets	(32)3 genetic	(50)2 docking,	(68)2 to
(15)5 changes	(33)3 imaging	(51)2 efficacy	(69)2 trajectory
(16)5 characterization	(34)3 initiating	(52)2 genetic,
(17)5 determinants	(35)3 mechanism,	(53)2 identity
(18)5 events	(36)3 pathology	(54)2 investigations

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--- WordNet output for molecular --- =>分子の Overview of adj molecular The adj molecular has 2 senses (first 1 from tagged texts) 1. (6) molecular -- (relating to or produced by or consisting of molecules; "molecular structure"; "molecular oxygen"; "molecular weight is the sum of all the atoms in a molecule") 2. molecular -- (relating to simple or elementary organization; "proceed by more and more detailed analysis to the molecular facts of perception"--G.A. Miller) --- WordNet end ---