ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for molecular out of >500 occurrences
333489 occurrences (No.56 in the rank) during 5 years in the PubMed. [no cache] 500 found
6) The comprehensive knowledge of the molecular mechanisms behind the association of metabolic alterations and cognitive impairment could facilitate the early detection of neurodegenerative diseases in patients with metabolic alterations, with treatment that focus on neuroprotection.
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PMID:24464982 DOI:10.1002/dmrr.2531
2015 Diabetes/metabolism research and reviews
* Cellular and metabolic alterations in the hippocampus caused by insulin signalling dysfunction and its association with cognitive impairment during aging and Alzheimer's disease: studies in animal models.
- A growing body of animal and epidemiological studies suggest that metabolic diseases such as obesity, insulin resistance, metabolic syndrome and type 2 diabetes mellitus are associated with the development of cognitive impairment, dementia and Alzheimer's disease, particularly in aging. Several lines of evidence suggest that insulin signalling dysfunction produces these metabolic alterations and underlie the development of these neurodegenerative diseases. In this article, we address normal insulin function in the synapse; we review and discuss the physiopathological hallmarks of synaptic insulin signalling dysfunction associated with metabolic alterations. Additionally, we describe and review the major animal models of obesity, insulin resistance, metabolic syndrome and type 2 diabetes mellitus. The comprehensive knowledge of the molecular mechanisms behind the association of metabolic alterations and cognitive impairment could facilitate the early detection of neurodegenerative diseases in patients with metabolic alterations, with treatment that focus on neuroprotection. It could also help in the development of metabolic-based therapies and drugs for using in dementia and Alzheimer's disease patients to alleviate their symptoms in a more efficient and comprehensive way.
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[frequency of next (right) word to molecular]
(1)52 mechanisms (19)5 docking (37)3 recognition (55)2 heparin
(2)26 weight (20)5 information (38)3 serotyping (56)2 identification
(3)18 data (21)5 methods (39)3 sieve (57)2 knowledge
(4)18 mechanism (22)5 modeling (40)3 structure (58)2 mass
(5)16 dynamics (23)5 phylogenetic (41)3 techniques (59)2 mechanisms,
(6)15 and (24)5 targets (42)3 variance (60)2 or
(7)10 analysis (25)4 diagnosis (43)2 Dynamics (61)2 oxygen
(8)10 basis (26)4 interactions (44)2 approach (62)2 perspectives
(9)8 characterization (27)4 level (45)2 biological (63)2 phenotypic
(10)7 epidemiology (28)4 level, (46)2 classification (64)2 phylogenies
(11)7 genetic (29)4 responses (47)2 clock (65)2 probes
(12)7 imaging (30)4 target (48)2 dating (66)2 profiles
(13)6 biology (31)3 evolution (49)2 details (67)2 subtype
(14)6 changes (32)3 features (50)2 diffusion (68)2 therapies
(15)6 markers (33)3 levels (51)2 effects (69)2 underpinnings
(16)6 pathways (34)3 marker (52)2 events
(17)5 analyses (35)3 medicine (53)2 evidence
(18)5 characteristics (36)3 orbital (54)2 genetics

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--- WordNet output for molecular --- =>分子の Overview of adj molecular The adj molecular has 2 senses (first 1 from tagged texts) 1. (6) molecular -- (relating to or produced by or consisting of molecules; "molecular structure"; "molecular oxygen"; "molecular weight is the sum of all the atoms in a molecule") 2. molecular -- (relating to simple or elementary organization; "proceed by more and more detailed analysis to the molecular facts of perception"--G.A. Miller) --- WordNet end ---