ELIZA

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486851 occurrences (No.30 in the rank) during 5 years in the PubMed. [cache]

207) This approach could facilitate the development of new drug delivery systems for the treatment of gliomas.

--- ABSTRACT ---

PMID:24437962 DOI:10.3109/10717544.2013.876460

2015 Drug delivery

* Treatment of glioma by cisplatin-loaded nanogels conjugated with monoclonal antibodies against Cx43 and BSAT1.

- Targeted drug delivery for brain tumor treatment is one of the important objectives in nanomedicine. Human glioblastoma is the most frequent and aggressive type of brain tumors. The preferential expression of membrane protein connexin 43 (Cx43) and brain-specific anion transporter (BSAT1) in the tumor and peritumoral area is a key component for targeted drug delivery. The purpose of this study was to design cisplatin-loaded nanogels conjugated with monoclonal antibodies to Cx43 and BSAT1 for treatment of intracranial gliomas 101/8. MRI volumetric analysis of tumor-bearing rats indicated significantly reduced tumor volume with cisplatin-loaded targeted-nanogel treatment compared to other formulations. The median survival of rats treated with targeted nanogels conjugated with specific mAbs against extracellular loops of Cx43 and BSAT1 were 27 and 26.6 days higher than that in control group, respectively. For the first time we demonstrated the efficiency of mAb-targeted cisplatin-loaded nanogels in the experimental model of glioma 101/8. This approach could facilitate the development of new drug delivery systems for the treatment of gliomas.

--- ABSTRACT END ---

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[frequency of next (right) word to new]

(1)19 Zealand	(19)4 targets	(37)2 Zealand,	(55)2 important
(2)13 bone	(20)3 DP	(38)2 avenues	(56)2 innovations
(3)12 approach	(21)3 York,	(39)2 biomarkers	(57)2 instrument
(4)11 and	(22)3 approaches	(40)2 blood	(58)2 methodologies
(5)10 method	(23)3 concepts	(41)2 case	(59)2 methods
(6)9 insights	(24)3 information	(42)2 cases	(60)2 parameters
(7)7 York	(25)3 insight	(43)2 challenges	(61)2 policy
(8)7 therapeutic	(26)3 light	(44)2 co-processed	(62)2 public
(9)5 data	(27)3 media	(45)2 compound	(63)2 risk
(10)5 molecular	(28)3 molecules	(46)2 concept	(64)2 strategies
(11)5 species	(29)3 regulation	(47)2 diagnostic	(65)2 strategy
(12)4 World	(30)3 research	(48)2 driver	(66)2 subspecies
(13)4 class	(31)3 technique	(49)2 drug	(67)2 training
(14)4 clinical	(32)3 treatment	(50)2 endemic	(68)2 type
(15)4 discoveries	(33)2 Graves'	(51)2 evidence	(69)2 way
(16)4 generation	(34)2 HIV	(52)2 findings
(17)4 measure	(35)2 South	(53)2 genetic
(18)4 model	(36)2 York/Japan	(54)2 health

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--- WordNet output for new --- =>新発見の, 新しい, 現代的な, 新参の Overview of adj new The adj new has 11 senses (first 5 from tagged texts) 1. (310) new -- (not of long duration; having just (or relatively recently) come into being or been made or acquired or discovered; "a new law"; "new cars"; "a new comet"; "a new friend"; "a new year"; "the New World") 2. (36) fresh, new, novel -- (original and of a kind not seen before; "the computer produced a completely novel proof of a well-known theorem") 3. (11) raw, new -- (lacking training or experience; "the new men were eager to fight"; "raw recruits") 4. (5) new, unexampled -- (having no previous example or precedent or parallel; "a time of unexampled prosperity") 5. (3) new -- (other than the former one(s); different; "they now have a new leaders"; "my new car is four years old but has only 15,000 miles on it"; "ready to take a new direction") 6. new -- (unaffected by use or exposure; "it looks like new") 7. newfangled, new -- ((of a new kind or fashion) gratuitously new; "newfangled ideas"; "she buys all these new-fangled machines and never uses them") 8. New -- (in use after medieval times; "New Eqyptian was the language of the 18th to 21st dynasties") 9. Modern, New -- (used of a living language; being the current stage in its development; "Modern English"; "New Hebrew is Israeli Hebrew") 10. new, young -- ((of crops) harvested at an early stage of development; before complete maturity; "new potatoes"; "young corn") 11. new -- (unfamiliar; "new experiences"; "experiences new to him"; "errors of someone new to the job") Overview of adv new The adv new has 1 sense (first 1 from tagged texts) 1. (1) newly, freshly, fresh, new -- (very recently; "they are newly married"; "newly raised objections"; "a newly arranged hairdo"; "grass new washed by the rain"; "a freshly cleaned floor"; "we are fresh out of tomatoes") --- WordNet end ---