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return kwic search for new out of >500 occurrences
486851 occurrences (No.30 in the rank) during 5 years in the PubMed. [cache]

234) New molecular targets are continually being sought that can halt CAVS progression.

--- ABSTRACT ---

PMID:33963260 DOI:10.1038/s41598-021-89164-w

2021 Scientific reports

* Collagen fiber regulation in human pediatric aortic valve development and disease.

- Congenital aortic valve stenosis (CAVS) affects up to 10% of the world population without medical therapies to treat the disease. New molecular targets are continually being sought that can halt CAVS progression. Collagen deregulation is a hallmark of CAVS yet remains mostly undefined. Here, histological studies were paired with high resolution accurate mass (HRAM) collagen-targeting proteomics to investigate collagen fiber production with collagen regulation associated with human AV development and pediatric end-stage CAVS (pCAVS). Histological studies identified collagen fiber realignment and unique regions of high-density collagen in pCAVS. Proteomic analysis reported specific collagen peptides are modified by hydroxylated prolines (HYP), a post-translational modification critical to stabilizing the collagen triple helix. Quantitative data analysis reported significant regulation of collagen HYP sites across patient categories. Non-collagen type ECM proteins identified (26 of the 44 total proteins) have direct interactions in collagen synthesis, regulation, or modification. Network analysis identified BAMBI (BMP and Activin Membrane Bound Inhibitor) as a potential upstream regulator of the collagen interactome. This is the first study to detail the collagen types and HYP modifications associated with human AV development and pCAVS. We anticipate that this study will inform new therapeutic avenues that inhibit valvular degradation in pCAVS and engineered options for valve replacement.

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[frequency of next (right) word to new]

(1)14 therapeutic	(21)3 Zealand,	(42)2 Guinea	(62)2 means
(2)12 and	(22)3 agents	(43)2 ICDF	(63)2 melatonin
(3)10 &	(23)3 approaches	(44)2 Mexico	(64)2 molecular
(4)9 technologies	(24)3 attention	(45)2 York	(65)2 opportunities
(5)8 method	(25)3 bone	(46)2 analytical	(66)2 pandemic
(6)7 insights	(26)3 cases	(47)2 avenue	(67)2 photoreceptors
(7)7 therapies	(27)3 challenges	(48)2 classifier	(68)2 population
(8)6 Zealand	(28)3 coronary	(49)2 computational	(69)2 preventive
(9)6 approach	(29)3 drug	(50)2 concept	(70)2 questionnaire
(10)6 diagnostic	(30)3 generation	(51)2 dimension	(71)2 severe
(11)6 treatment	(31)3 information	(52)2 direction	(72)2 strategies,
(12)5 class	(32)3 insight	(53)2 discoveries	(73)2 target
(13)5 data	(33)3 model	(54)2 drugs	(74)2 targets
(14)4 ADHD	(34)3 non-invasive	(55)2 drugs,	(75)2 theoretical
(15)4 avenues	(35)3 research	(56)2 era	(76)2 tool
(16)4 chemical	(36)3 strategies	(57)2 evidence	(77)2 type
(17)4 light	(37)3 tests	(58)2 findings	(78)2 viruses
(18)4 methods	(38)3 types	(59)2 forms
(19)4 treatments	(40)2 AF	(60)2 knowledge
(20)3 England	(41)2 COVID-19	(61)2 materials,

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--- WordNet output for new --- =>新発見の, 新しい, 現代的な, 新参の Overview of adj new The adj new has 11 senses (first 5 from tagged texts) 1. (310) new -- (not of long duration; having just (or relatively recently) come into being or been made or acquired or discovered; "a new law"; "new cars"; "a new comet"; "a new friend"; "a new year"; "the New World") 2. (36) fresh, new, novel -- (original and of a kind not seen before; "the computer produced a completely novel proof of a well-known theorem") 3. (11) raw, new -- (lacking training or experience; "the new men were eager to fight"; "raw recruits") 4. (5) new, unexampled -- (having no previous example or precedent or parallel; "a time of unexampled prosperity") 5. (3) new -- (other than the former one(s); different; "they now have a new leaders"; "my new car is four years old but has only 15,000 miles on it"; "ready to take a new direction") 6. new -- (unaffected by use or exposure; "it looks like new") 7. newfangled, new -- ((of a new kind or fashion) gratuitously new; "newfangled ideas"; "she buys all these new-fangled machines and never uses them") 8. New -- (in use after medieval times; "New Eqyptian was the language of the 18th to 21st dynasties") 9. Modern, New -- (used of a living language; being the current stage in its development; "Modern English"; "New Hebrew is Israeli Hebrew") 10. new, young -- ((of crops) harvested at an early stage of development; before complete maturity; "new potatoes"; "young corn") 11. new -- (unfamiliar; "new experiences"; "experiences new to him"; "errors of someone new to the job") Overview of adv new The adv new has 1 sense (first 1 from tagged texts) 1. (1) newly, freshly, fresh, new -- (very recently; "they are newly married"; "newly raised objections"; "a newly arranged hairdo"; "grass new washed by the rain"; "a freshly cleaned floor"; "we are fresh out of tomatoes") --- WordNet end ---