ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
return
kwic search for new out of >500 occurrences
486851 occurrences (No.30 in the rank) during 5 years in the PubMed. [cache]
84) The selection of multiresistant microorganisms, as a side-effect of the use of antimicrobials, together with the lack of new therapeutic drugs expected in the near future, forces to a rational use of antibiotics.
2015 Enfermedades infecciosas y microbiologia clinica
* [Pharmacokinetic/pharmacodynamic analysis in microbiology: a tool for the evaluation of the antimicrobial treatment].
- The selection of multiresistant microorganisms, as a side-effect of the use of antimicrobials, together with the lack of new therapeutic drugs expected in the near future, forces to a rational use of antibiotics. The optimisation of antibacterial treatments based on pharmacokinetic/pharmacodynamic analysis (PK/PD) may contribute to prolong the life of antibiotics and to contain the bacterial resistance to them. A review is made of the importance of the appropriateness of the dose regimen selected, the application of PK/PD analysis of antimicrobials, the Monte Carlo simulation, PK/PD indices for efficacy, and PK/PD cut-off points. PK/PD analysis is also applicable to the prevention of bacterial resistance. Different methods have been used to study the factors that lead to its emergence and spread, such as in vitro and animal models, and resistance prevention studies (mutant selection window). Although the PK/PD analysis is a very useful tool for the selection of the most appropriate dose regimen of antibiotics, several problems limit its use in clinical practice.
=>新発見の, 新しい, 現代的な, 新参の
Overview of adj new
The adj new has 11 senses (first 5 from tagged texts)
1. (310) new -- (not of long duration; having just (or relatively recently) come into being or been
made or acquired or discovered; "a new law"; "new cars"; "a new comet"; "a new friend"; "a new
year"; "the New World")
2. (36) fresh, new, novel -- (original and of a kind not seen before; "the computer produced a
completely novel proof of a well-known theorem")
3. (11) raw, new -- (lacking training or experience; "the new men were eager to fight"; "raw
recruits")
4. (5) new, unexampled -- (having no previous example or precedent or parallel; "a time of
unexampled prosperity")
5. (3) new -- (other than the former one(s); different; "they now have a new leaders"; "my new car
is four years old but has only 15,000 miles on it"; "ready to take a new direction")
6. new -- (unaffected by use or exposure; "it looks like new")
7. newfangled, new -- ((of a new kind or fashion) gratuitously new; "newfangled ideas"; "she buys
all these new-fangled machines and never uses them")
8. New -- (in use after medieval times; "New Eqyptian was the language of the 18th to 21st
dynasties")
9. Modern, New -- (used of a living language; being the current stage in its development; "Modern
English"; "New Hebrew is Israeli Hebrew")
10. new, young -- ((of crops) harvested at an early stage of development; before complete maturity;
"new potatoes"; "young corn")
11. new -- (unfamiliar; "new experiences"; "experiences new to him"; "errors of someone new to the
job")
Overview of adv new
The adv new has 1 sense (first 1 from tagged texts)
1. (1) newly, freshly, fresh, new -- (very recently; "they are newly married"; "newly raised
objections"; "a newly arranged hairdo"; "grass new washed by the rain"; "a freshly cleaned floor";
"we are fresh out of tomatoes")
--- WordNet end ---