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return kwic search for novel out of >500 occurrences
330250 occurrences (No.59 in the rank) during 5 years in the PubMed. [cache]

162) Hence, our study suggested that STING could serve as a potential novel immunotherapeutic target for cervical cancer.

--- ABSTRACT ---

PMID:33141310 DOI:10.1007/s11010-020-03967-5

2021 Molecular and cellular biochemistry

* Activation of STING inhibits cervical cancer tumor growth through enhancing the anti-tumor immune response.

- Cervical cancer remains the second leading cause of gynecologic cancer-related mortality among women worldwide. STING (stimulator of interferon genes) was reported to be involved in the immune surveillance of tumors. However, the specific role of STING in cervical cancer remains unclear. In this study, we found that the cGAS (Cyclic GMP-AMP synthase)/STING signal decreased in cervical cancer cells. Knockdown of STING by siRNA enhanced the cell viability and migration of cervical cancer cells, while activation of STING by ADU-S100 inhibited the cell viability of cervical cancer cells, with no effect on the migration and apoptosis. In addition, ADU-S100 promoted the secretion of IFNβ and IL-6, and the activation of TBK1 (TANK-binding kinase 1)/NF-κB (nuclear factor kappa-B) pathway. Meanwhile, knockdown of STING inhibited the production of IFNβ and IL-6 that were triggered by dsDNA and suppressed the TBK1/NF-κB signaling. ADU-S100 also suppressed tumor growth in vivo and increased the tumor-infiltrating CD8⁺ T cell and CD103⁺ dendritic cell numbers. The NF-κB signal inhibitor limited the increasing numbers of CD8⁺ T cell and CD103⁺ dendritic cells induced by ADU-S100, without influence on tumor growth. Hence, our study suggested that STING could serve as a potential novel immunotherapeutic target for cervical cancer.

--- ABSTRACT END ---

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[frequency of next (right) word to novel]

(1)23 therapeutic	(18)4 strategy	(35)2 antifungal	(52)2 nonsteroidal
(2)14 approach	(19)4 therapeutics	(36)2 biomarker	(53)2 object
(3)11 and	(20)3 STAT3	(37)2 biomarkers	(54)2 opportunities
(4)10 coronavirus	(21)3 avenues	(38)2 blood	(55)2 perspectives
(5)8 insights	(22)3 bicistronic	(39)2 cardiac	(56)2 pharmaceutical
(6)8 mechanism	(23)3 compound	(40)2 cell-based	(57)2 preclinical
(7)7 method	(24)3 diagnostic	(41)2 class	(58)2 protein
(8)6 chemical	(25)3 drugs	(42)2 dietary	(59)2 proteins
(9)6 role	(26)3 genetic	(43)2 evidence-based	(60)2 reactive
(10)6 therapies	(27)3 immunotherapeutic	(44)2 human	(61)2 risk
(11)6 treatment	(28)3 methodologies	(45)2 imaging	(62)2 small-molecule
(12)5 approaches	(29)3 mouse	(46)2 infectious	(63)2 target
(13)5 drug	(30)3 small	(47)2 insight	(64)2 targets
(14)4 data	(31)2 Coronavirus	(48)2 interventions	(65)2 trial
(15)4 findings	(32)2 agents	(49)2 methodology
(16)4 in	(33)2 analgesic	(50)2 neuroprotective
(17)4 strategies	(34)2 analytical	(51)2 noninvasive

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--- WordNet output for novel --- =>1.よく知られていない, 新しい, 珍奇な, 異常な, 新奇な, 目新しい, 2.(長編)小説 Overview of noun novel The noun novel has 2 senses (first 1 from tagged texts) 1. (17) novel -- (an extended fictional work in prose; usually in the form of a story) 2. novel -- (a printed and bound book that is an extended work of fiction; "his bookcases were filled with nothing but novels"; "he burned all the novels") Overview of adj novel The adj novel has 2 senses (first 1 from tagged texts) 1. (6) fresh, new, novel -- (original and of a kind not seen before; "the computer produced a completely novel proof of a well-known theorem") 2. novel, refreshing -- (pleasantly new or different; "common sense of a most refreshing sort") --- WordNet end ---