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return kwic search for novel out of >500 occurrences
330250 occurrences (No.59 in the rank) during 5 years in the PubMed. [no cache] 500 found

18) A better understanding of how alcohol affects these diverse and interlinked mechanisms may lead to the identification of novel therapeutic targets and to the development of much-needed novel and efficacious treatment options.

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PMID:34702580 DOI:10.1016/j.tins.2021.09.006

2021 Trends in neurosciences

* Alcohol and the brain: from genes to circuits.

- Alcohol use produces wide-ranging and diverse effects on the central nervous system. It influences intracellular signaling mechanisms, leading to changes in gene expression, chromatin remodeling, and translation. As a result of these molecular alterations, alcohol affects the activity of neuronal circuits. Together, these mechanisms produce long-lasting cellular adaptations in the brain that in turn can drive the development and maintenance of alcohol use disorder (AUD). We provide an update on alcohol research, focusing on multiple levels of alcohol-induced adaptations, from intracellular changes to changes in neural circuits. A better understanding of how alcohol affects these diverse and interlinked mechanisms may lead to the identification of novel therapeutic targets and to the development of much-needed novel and efficacious treatment options.

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[frequency of next (right) word to novel]

(1)23 therapeutic	(18)4 strategy	(35)2 antifungal	(52)2 nonsteroidal
(2)14 approach	(19)4 therapeutics	(36)2 biomarker	(53)2 object
(3)11 and	(20)3 STAT3	(37)2 biomarkers	(54)2 opportunities
(4)10 coronavirus	(21)3 avenues	(38)2 blood	(55)2 perspectives
(5)8 insights	(22)3 bicistronic	(39)2 cardiac	(56)2 pharmaceutical
(6)8 mechanism	(23)3 compound	(40)2 cell-based	(57)2 preclinical
(7)7 method	(24)3 diagnostic	(41)2 class	(58)2 protein
(8)6 chemical	(25)3 drugs	(42)2 dietary	(59)2 proteins
(9)6 role	(26)3 genetic	(43)2 evidence-based	(60)2 reactive
(10)6 therapies	(27)3 immunotherapeutic	(44)2 human	(61)2 risk
(11)6 treatment	(28)3 methodologies	(45)2 imaging	(62)2 small-molecule
(12)5 approaches	(29)3 mouse	(46)2 infectious	(63)2 target
(13)5 drug	(30)3 small	(47)2 insight	(64)2 targets
(14)4 data	(31)2 Coronavirus	(48)2 interventions	(65)2 trial
(15)4 findings	(32)2 agents	(49)2 methodology
(16)4 in	(33)2 analgesic	(50)2 neuroprotective
(17)4 strategies	(34)2 analytical	(51)2 noninvasive

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--- WordNet output for novel --- =>1.よく知られていない, 新しい, 珍奇な, 異常な, 新奇な, 目新しい, 2.(長編)小説 Overview of noun novel The noun novel has 2 senses (first 1 from tagged texts) 1. (17) novel -- (an extended fictional work in prose; usually in the form of a story) 2. novel -- (a printed and bound book that is an extended work of fiction; "his bookcases were filled with nothing but novels"; "he burned all the novels") Overview of adj novel The adj novel has 2 senses (first 1 from tagged texts) 1. (6) fresh, new, novel -- (original and of a kind not seen before; "the computer produced a completely novel proof of a well-known theorem") 2. novel, refreshing -- (pleasantly new or different; "common sense of a most refreshing sort") --- WordNet end ---