ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for novel out of >500 occurrences
330250 occurrences (No.59 in the rank) during 5 years in the PubMed. [no cache] 500 found
21) The current findings indicate that UHMWPE particles stimulate NKT cells/DCs to produce pro-inflammatory cytokines; this pathway is a novel therapeutic target to mitigate wear particle induced peri-prosthetic osteolysis.
--- ABSTRACT ---
PMID:24616165 DOI:10.1002/jbm.a.35159
2015 Journal of biomedical materials research. Part A
* Exposure of polyethylene particles induces interferon-γ expression in a natural killer T lymphocyte and dendritic cell coculture system in vitro: a preliminary study.
- Two major issues in total joint arthroplasty are loosening of implants and osteolysis caused by wear particle-induced inflammation. Wear particles stimulate the release of pro-inflammatory cytokines, chemokines, and other inflammatory mediators from macrophages and other cells. Although the biological response of macrophages to wear debris is well established, the role of other cell types such as natural killer T lymphocytes (NKT) and dendritic cells (DCs) is limited. Here we show that ultra-high molecular weight polyethylene (UHMWPE) particles stimulate NKT cells to secrete Interferon-γ (IFN-γ); coculture with DCs further enhanced IFN-γ secretion. Furthermore, UHMWPE particles did not stimulate NKT cells to secrete IL-4, while the NKT cell natural ligand α-galactosylceramide (α-GalCer) treatment in the coculture system significantly enhanced both IFN-γ and IL-4 expression by NKT cells. Comparatively, NKT cells and/or DCs exposed to polymethylmethacrylate particles did not stimulate IFN-γ or IL-4 expression. Mouse bone marrow derived macrophage polarization by lipopolysaccharide and conditioned medium from NKT cells and/or DCs exposed to UHMWPE particles increased tumor necrosis factor-α (TNF-α), but reduced arginase-1 expression in macrophages. The current findings indicate that UHMWPE particles stimulate NKT cells/DCs to produce pro-inflammatory cytokines; this pathway is a novel therapeutic target to mitigate wear particle induced peri-prosthetic osteolysis.
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(1)22 therapeutic (17)3 mutation (33)2 approaches (49)2 information
(2)11 and (18)3 paradigm (34)2 autosomal (50)2 inhibitors
(3)8 mechanism (19)3 role (35)2 candidate (51)2 learning
(4)8 method (20)3 strain (36)2 cardiac (52)2 modulators
(5)7 approach (21)3 target (37)2 clinical (53)2 object
(6)7 mutations (22)3 targeted (38)2 compounds (54)2 oral
(7)6 therapies (23)3 targets (39)2 data (55)2 polymer
(8)5 technique (24)3 treatment (40)2 described (56)2 potent
(9)4 strategies (25)3 type (41)2 dual (57)2 prognostic
(10)4 strategy (26)3 words (42)2 electroporation (58)2 putative
(11)4 surgical (27)2 *null* (43)2 finding (59)2 recombinants
(12)3 antibacterial (28)2 anti-tumor (44)2 findings (60)2 results
(13)3 drug (29)2 antibiotic (45)2 form (61)2 therapeutical
(14)3 homozygous (30)2 anticancer (46)2 genetic (62)2 titanium
(15)3 insights (31)2 application (47)2 imaging (63)2 treatments
(16)3 mechanisms (32)2 applications (48)2 in

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--- WordNet output for novel --- =>1.よく知られていない, 新しい, 珍奇な, 異常な, 新奇な, 目新しい, 2.(長編)小説 Overview of noun novel The noun novel has 2 senses (first 1 from tagged texts) 1. (17) novel -- (an extended fictional work in prose; usually in the form of a story) 2. novel -- (a printed and bound book that is an extended work of fiction; "his bookcases were filled with nothing but novels"; "he burned all the novels") Overview of adj novel The adj novel has 2 senses (first 1 from tagged texts) 1. (6) fresh, new, novel -- (original and of a kind not seen before; "the computer produced a completely novel proof of a well-known theorem") 2. novel, refreshing -- (pleasantly new or different; "common sense of a most refreshing sort") --- WordNet end ---