ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for novel out of >500 occurrences
330250 occurrences (No.59 in the rank) during 5 years in the PubMed. [no cache] 500 found
22) These findings allow better understanding of the mechanisms involved in cell-to-cell interaction and may have interesting implications for the development of novel therapeutic tools in place of the parent cells.
--- ABSTRACT ---
PMID:24268069 DOI:10.3727/096368913X675728
2015 Cell transplantation
* Recent advances in mesenchymal stem cell immunomodulation: the role of microvesicles.
- Mesenchymal stem cells are the most widely used cell phenotype for therapeutic applications, the main reasons being their well-established abilities to promote regeneration of injured tissues and to modulate immune responses. Efficacy was reported in the treatment of several animal models of inflammatory and autoimmune diseases and, in clinical settings, for the management of disorders such as GVHD, systemic lupus erythematosus, multiple sclerosis, and inflammatory bowel disease. The effects of mesenchymal stem cells are believed to be largely mediated by paracrine signals, and several secreted molecules have been identified as contributors to the net biological effect. Recently, it has been recognized that bioactive molecules can be shuttled from cell to cell packed in microvesicles, tiny portions of cytoplasm surrounded by a membrane. Coding and noncoding RNAs are also carried in such microvesicles, transferring relevant biological activity to target cells. Several reports indicate that the regenerative effect of mesenchymal stem cells can be reproduced by microvesicles isolated from their culture medium. More recent evidence suggests that the immunomodulatory effects of mesenchymal stem cells are also at least partially mediated by secreted microvesicles. These findings allow better understanding of the mechanisms involved in cell-to-cell interaction and may have interesting implications for the development of novel therapeutic tools in place of the parent cells.
--- ABSTRACT END ---
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(1)22 therapeutic (17)3 mutation (33)2 approaches (49)2 information
(2)11 and (18)3 paradigm (34)2 autosomal (50)2 inhibitors
(3)8 mechanism (19)3 role (35)2 candidate (51)2 learning
(4)8 method (20)3 strain (36)2 cardiac (52)2 modulators
(5)7 approach (21)3 target (37)2 clinical (53)2 object
(6)7 mutations (22)3 targeted (38)2 compounds (54)2 oral
(7)6 therapies (23)3 targets (39)2 data (55)2 polymer
(8)5 technique (24)3 treatment (40)2 described (56)2 potent
(9)4 strategies (25)3 type (41)2 dual (57)2 prognostic
(10)4 strategy (26)3 words (42)2 electroporation (58)2 putative
(11)4 surgical (27)2 *null* (43)2 finding (59)2 recombinants
(12)3 antibacterial (28)2 anti-tumor (44)2 findings (60)2 results
(13)3 drug (29)2 antibiotic (45)2 form (61)2 therapeutical
(14)3 homozygous (30)2 anticancer (46)2 genetic (62)2 titanium
(15)3 insights (31)2 application (47)2 imaging (63)2 treatments
(16)3 mechanisms (32)2 applications (48)2 in

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--- WordNet output for novel --- =>1.よく知られていない, 新しい, 珍奇な, 異常な, 新奇な, 目新しい, 2.(長編)小説 Overview of noun novel The noun novel has 2 senses (first 1 from tagged texts) 1. (17) novel -- (an extended fictional work in prose; usually in the form of a story) 2. novel -- (a printed and bound book that is an extended work of fiction; "his bookcases were filled with nothing but novels"; "he burned all the novels") Overview of adj novel The adj novel has 2 senses (first 1 from tagged texts) 1. (6) fresh, new, novel -- (original and of a kind not seen before; "the computer produced a completely novel proof of a well-known theorem") 2. novel, refreshing -- (pleasantly new or different; "common sense of a most refreshing sort") --- WordNet end ---