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- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
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330250 occurrences (No.59 in the rank) during 5 years in the PubMed. [no cache] 500 found
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330250 occurrences (No.59 in the rank) during 5 years in the PubMed. [no cache] 500 found
| 31) Here, we review recent studies that have unraveled novel and unique contributions of astrocytes to the generation and spread of convulsive and nonconvulsive seizures and epileptiform activity. |
| PMID:24609207 DOI:10.1177/1073858414523320 |
| 2015 The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry |
| * Novel astrocyte targets: new avenues for the therapeutic treatment of epilepsy. |
| - During the last 20 years, it has been well established that a finely tuned, continuous crosstalk between neurons and astrocytes not only critically modulates physiological brain functions but also underlies many neurological diseases. In particular, this novel way of interpreting brain activity is markedly influencing our current knowledge of epilepsy, prompting a re-evaluation of old findings and guiding novel experimentation. Here, we review recent studies that have unraveled novel and unique contributions of astrocytes to the generation and spread of convulsive and nonconvulsive seizures and epileptiform activity. The emerging scenario advocates an overall framework in which a dynamic and reciprocal interplay among astrocytic and neuronal ensembles is fundamental for a fuller understanding of epilepsy. In turn, this offers novel astrocytic targets for the development of those really novel chemical entities for the control of convulsive and nonconvulsive seizures that have been acknowledged as a key priority in the management of epilepsy. |
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