ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for novel out of >500 occurrences
330250 occurrences (No.59 in the rank) during 5 years in the PubMed. [no cache] 500 found
5) We also examine the intersection between alternative splicing pathways and novel therapeutic approaches.
--- ABSTRACT ---
PMID:24441040 DOI:10.1038/onc.2013.570
2015 Oncogene
* Alternative splicing in cancer: implications for biology and therapy.
- Alternative splicing has critical roles in normal development and can promote growth and survival in cancer. Aberrant splicing, the production of noncanonical and cancer-specific mRNA transcripts, can lead to loss-of-function in tumor suppressors or activation of oncogenes and cancer pathways. Emerging data suggest that aberrant splicing products and loss of canonically spliced variants correlate with stage and progression in malignancy. Here, we review the splicing landscape of TP53, BARD1 and AR to illuminate roles for alternative splicing in cancer. We also examine the intersection between alternative splicing pathways and novel therapeutic approaches.
--- ABSTRACT END ---
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(1)22 therapeutic (17)3 mutation (33)2 approaches (49)2 information
(2)11 and (18)3 paradigm (34)2 autosomal (50)2 inhibitors
(3)8 mechanism (19)3 role (35)2 candidate (51)2 learning
(4)8 method (20)3 strain (36)2 cardiac (52)2 modulators
(5)7 approach (21)3 target (37)2 clinical (53)2 object
(6)7 mutations (22)3 targeted (38)2 compounds (54)2 oral
(7)6 therapies (23)3 targets (39)2 data (55)2 polymer
(8)5 technique (24)3 treatment (40)2 described (56)2 potent
(9)4 strategies (25)3 type (41)2 dual (57)2 prognostic
(10)4 strategy (26)3 words (42)2 electroporation (58)2 putative
(11)4 surgical (27)2 *null* (43)2 finding (59)2 recombinants
(12)3 antibacterial (28)2 anti-tumor (44)2 findings (60)2 results
(13)3 drug (29)2 antibiotic (45)2 form (61)2 therapeutical
(14)3 homozygous (30)2 anticancer (46)2 genetic (62)2 titanium
(15)3 insights (31)2 application (47)2 imaging (63)2 treatments
(16)3 mechanisms (32)2 applications (48)2 in

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--- WordNet output for novel --- =>1.よく知られていない, 新しい, 珍奇な, 異常な, 新奇な, 目新しい, 2.(長編)小説 Overview of noun novel The noun novel has 2 senses (first 1 from tagged texts) 1. (17) novel -- (an extended fictional work in prose; usually in the form of a story) 2. novel -- (a printed and bound book that is an extended work of fiction; "his bookcases were filled with nothing but novels"; "he burned all the novels") Overview of adj novel The adj novel has 2 senses (first 1 from tagged texts) 1. (6) fresh, new, novel -- (original and of a kind not seen before; "the computer produced a completely novel proof of a well-known theorem") 2. novel, refreshing -- (pleasantly new or different; "common sense of a most refreshing sort") --- WordNet end ---