* Long-term effect of telmisartan on Alzheimer's amyloid genesis in SHR-SR after tMCAO.
- Telmisartan is expected to reduce not only the level of blood pressure but also neuroinflammation and neurotoxicity via pleiotrophic effects as a metabo-sartan. We examined the effects of telmisartan on Alzheimer's disease (AD) pathology in spontaneously hypertensive rat stroke resistant (SHR-SR) after transient middle cerebral artery occlusion (tMCAO) by giving either telmisartan at 0 (vehicle), 0.3 mg/kg/day (low dose, with no reduction of blood pressure), or 3 mg/kg/day (high dose, with a significant reduction of blood pressure) p.o. from 3 months (M) of age, and performed immunohistological analysis at 6, 12, and 18 M of age. The numbers of amyloid β (Aβ)-positive neurons in the cerebral cortex and hippocampus and senile plaque (SP) in the ipsilateral cerebral cortex progressively increased with age until 18 M in the SHR-SR after tMCAO. On the other hand, low-dose telmisartan significantly reduced the number of Aβ-positive neuron as well as SP at 6, 12, and 18 M. High-dose telmisartan showed further reductions of the above AD pathology. The present study suggests that telmisartan reduced both intracellular Aβ and extracellular SP accumulations after tMCAO in SHR-SR, with a further improvement by combined BP lowering. Such a strong effect of telmisartan could provide a preventative approach for AD in post-stroke patients with hypertension.
=>に番号をつける, 数, 番号, 総数, 若干, 多数, 曲, 過ごす, 達する, 番号を唱える
Overview of noun number
The noun number has 11 senses (first 9 from tagged texts)
1. (131) number, figure -- (the property possessed by a sum or total or indefinite quantity of units
or individuals; "he had a number of chores to do"; "the number of parameters is small"; "the figure
was about a thousand")
2. (63) number -- (a concept of quantity involving zero and units; "every number has a unique
position in the sequence")
3. (5) act, routine, number, turn, bit -- (a short theatrical performance that is part of a longer
program; "he did his act three times every evening"; "she had a catchy little routine"; "it was one
of the best numbers he ever did")
4. (5) phone number, telephone number, number -- (the number is used in calling a particular
telephone; "he has an unlisted number")
5. (2) numeral, number -- (a symbol used to represent a number; "he learned to write the numerals
before he went to school")
6. (2) issue, number -- (one of a series published periodically; "she found an old issue of the
magazine in her dentist's waiting room")
7. (1) number -- (a select company of people; "I hope to become one of their number before I die")
8. (1) number, identification number -- (a numeral or string of numerals that is used for
identification; "she refused to give them her Social Security number")
9. (1) number -- (a clothing measurement; "a number 13 shoe")
10. number -- (the grammatical category for the forms of nouns and pronouns and verbs that are used
depending on the number of entities involved (singular or dual or plural); "in English the subject
and the verb must agree in number")
11. number -- (an item of merchandise offered for sale; "she preferred the black nylon number";
"this sweater is an all-wool number")
Overview of verb number
The verb number has 6 senses (first 3 from tagged texts)
1. (6) total, number, add up, come, amount -- (add up in number or quantity; "The bills amounted to
$2,000"; "The bill came to $2,000")
2. (2) number -- (give numbers to; "You should number the pages of the thesis")
3. (1) number, list -- (enumerate; "We must number the names of the great mathematicians")
4. count, number -- (put into a group; "The academy counts several Nobel Prize winners among its
members")
5. count, number, enumerate, numerate -- (determine the number or amount of; "Can you count the
books on your shelf?"; "Count your change")
6. number, keep down -- (place a limit on the number of)
--- WordNet end ---