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308018 occurrences (No.72 in the rank) during 5 years in the PubMed. [no cache]
500 found
18) According to the bioequivalence guidelines, the area under the blood concentration - time curve by 48 hours after administration (AUC0-48) in a single intravenous drip (IVD) study, and AUC0-48 and maximum blood concentration (Cmax) in a single subcutaneous (SC) dose study were used as primary endpoints, and the pharmacodynamic parameters including absolute neutrophil count (ANC) or number of CD34 positive cells (CD34(+) cells) as secondary endpoints.
* Pharmacokinetics and pharmacodynamics of FSK0808 and Gran after single intravenous drip administration or single subcutaneous administration: comparative study in healthy Japanese adult male subjects.
- FSK0808 is a recombinant human granulocyte colony-stimulating factor developed by Fuji Pharma Co., Ltd and Mochida Pharmaceutical Co., Ltd. as a biosimilar product of Gran®. We verified the pharmacokinetic/pharmacodynamic equivalence of FSK0808 and commercially available Gran® by a randomized crossover study of single intravenous dose (200 µg/m(2)) and single subcutaneous dose (400 µg/m(2)) in healthy Japanese adult male subjects. According to the bioequivalence guidelines, the area under the blood concentration - time curve by 48 hours after administration (AUC0-48) in a single intravenous drip (IVD) study, and AUC0-48 and maximum blood concentration (Cmax) in a single subcutaneous (SC) dose study were used as primary endpoints, and the pharmacodynamic parameters including absolute neutrophil count (ANC) or number of CD34 positive cells (CD34(+) cells) as secondary endpoints. The safety was evaluated based on the characteristics and incidence of adverse reactions. As a result, the 90% confidence interval (CI) of the difference in mean value for AUC0-48 among drugs ranged from log(0.8) to log(1.25), in the IVD study, and those for Cmax and AUC0-48 were within the range of log(0.8)-log(1.25) in the SC study. Those for secondary endpoints were all within the range of log(0.8)-log(1.25). Thus, the pharmacokinetics/pharmacodynamics of both drugs were considered equivalent for all routes of administration, and the profiles of adverse reactions were also very similar.
=>に番号をつける, 数, 番号, 総数, 若干, 多数, 曲, 過ごす, 達する, 番号を唱える
Overview of noun number
The noun number has 11 senses (first 9 from tagged texts)
1. (131) number, figure -- (the property possessed by a sum or total or indefinite quantity of units
or individuals; "he had a number of chores to do"; "the number of parameters is small"; "the figure
was about a thousand")
2. (63) number -- (a concept of quantity involving zero and units; "every number has a unique
position in the sequence")
3. (5) act, routine, number, turn, bit -- (a short theatrical performance that is part of a longer
program; "he did his act three times every evening"; "she had a catchy little routine"; "it was one
of the best numbers he ever did")
4. (5) phone number, telephone number, number -- (the number is used in calling a particular
telephone; "he has an unlisted number")
5. (2) numeral, number -- (a symbol used to represent a number; "he learned to write the numerals
before he went to school")
6. (2) issue, number -- (one of a series published periodically; "she found an old issue of the
magazine in her dentist's waiting room")
7. (1) number -- (a select company of people; "I hope to become one of their number before I die")
8. (1) number, identification number -- (a numeral or string of numerals that is used for
identification; "she refused to give them her Social Security number")
9. (1) number -- (a clothing measurement; "a number 13 shoe")
10. number -- (the grammatical category for the forms of nouns and pronouns and verbs that are used
depending on the number of entities involved (singular or dual or plural); "in English the subject
and the verb must agree in number")
11. number -- (an item of merchandise offered for sale; "she preferred the black nylon number";
"this sweater is an all-wool number")
Overview of verb number
The verb number has 6 senses (first 3 from tagged texts)
1. (6) total, number, add up, come, amount -- (add up in number or quantity; "The bills amounted to
$2,000"; "The bill came to $2,000")
2. (2) number -- (give numbers to; "You should number the pages of the thesis")
3. (1) number, list -- (enumerate; "We must number the names of the great mathematicians")
4. count, number -- (put into a group; "The academy counts several Nobel Prize winners among its
members")
5. count, number, enumerate, numerate -- (determine the number or amount of; "Can you count the
books on your shelf?"; "Count your change")
6. number, keep down -- (place a limit on the number of)
--- WordNet end ---