ELIZA

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308018 occurrences (No.72 in the rank) during 5 years in the PubMed. [no cache] 500 found

19) BK5.Stat3C transgenic (Tg) mice, which express a constitutively active form of Stat3 (Stat3C) in the basal layer of the epidermis and in the bulge region KSCs exhibited a significantly reduced number of CD34+/α6 integrin+ cells compared to non-transgenic (NTg) littermates.

--- ABSTRACT ---

PMID:24038534 DOI:10.1002/mc.22080

2015 Molecular carcinogenesis

* Constitutive Stat3 activation alters behavior of hair follicle stem and progenitor cell populations.

- STATs play crucial roles in a wide variety of biological functions, including development, proliferation, differentiation and migration as well as in cancer development. In the present study, we examined the impact of constitutive activation of Stat3 on behavior of keratinocytes, including keratinocyte stem cells (KSC) in vivo. BK5.Stat3C transgenic (Tg) mice, which express a constitutively active form of Stat3 (Stat3C) in the basal layer of the epidermis and in the bulge region KSCs exhibited a significantly reduced number of CD34+/α6 integrin+ cells compared to non-transgenic (NTg) littermates. There was a concomitant increase in the Lgr-6, Lrig-1, and Sca-1 populations in the Tg mice in contrast to the CD34 and Keratin-15 positive population. In addition, increased expression of c-myc, β-catenin, and epithelial-mesenchymal transition (EMT)-related genes as well as decreased expression of α6-integrin was observed in the hair follicles of Tg mice. Notably, Sca-1 was found to be a direct transcriptional target of Stat3 in keratinocytes. The current data suggest that elevated Stat3 activity leads to depletion of hair follicle KSCs along with a concomitant increase of stem/progenitor cells above the bulge region. Overall, the current data indicate that Stat3 plays an important role in keratinocyte stem/progenitor cell homeostasis.

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(1)420 of	(4)4 null	(7)2 as	(10)2 needed
(2)13 and	(5)3 line	(8)2 however,
(3)7 in	(6)3 than	(9)2 increased

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--- WordNet output for number --- =>に番号をつける, 数, 番号, 総数, 若干, 多数, 曲, 過ごす, 達する, 番号を唱える Overview of noun number The noun number has 11 senses (first 9 from tagged texts) 1. (131) number, figure -- (the property possessed by a sum or total or indefinite quantity of units or individuals; "he had a number of chores to do"; "the number of parameters is small"; "the figure was about a thousand") 2. (63) number -- (a concept of quantity involving zero and units; "every number has a unique position in the sequence") 3. (5) act, routine, number, turn, bit -- (a short theatrical performance that is part of a longer program; "he did his act three times every evening"; "she had a catchy little routine"; "it was one of the best numbers he ever did") 4. (5) phone number, telephone number, number -- (the number is used in calling a particular telephone; "he has an unlisted number") 5. (2) numeral, number -- (a symbol used to represent a number; "he learned to write the numerals before he went to school") 6. (2) issue, number -- (one of a series published periodically; "she found an old issue of the magazine in her dentist's waiting room") 7. (1) number -- (a select company of people; "I hope to become one of their number before I die") 8. (1) number, identification number -- (a numeral or string of numerals that is used for identification; "she refused to give them her Social Security number") 9. (1) number -- (a clothing measurement; "a number 13 shoe") 10. number -- (the grammatical category for the forms of nouns and pronouns and verbs that are used depending on the number of entities involved (singular or dual or plural); "in English the subject and the verb must agree in number") 11. number -- (an item of merchandise offered for sale; "she preferred the black nylon number"; "this sweater is an all-wool number") Overview of verb number The verb number has 6 senses (first 3 from tagged texts) 1. (6) total, number, add up, come, amount -- (add up in number or quantity; "The bills amounted to $2,000"; "The bill came to $2,000") 2. (2) number -- (give numbers to; "You should number the pages of the thesis") 3. (1) number, list -- (enumerate; "We must number the names of the great mathematicians") 4. count, number -- (put into a group; "The academy counts several Nobel Prize winners among its members") 5. count, number, enumerate, numerate -- (determine the number or amount of; "Can you count the books on your shelf?"; "Count your change") 6. number, keep down -- (place a limit on the number of) --- WordNet end ---