ELIZA

return kwic search for number out of >500 occurrences
308018 occurrences (No.72 in the rank) during 5 years in the PubMed. [cache]

432) In males, CRS induced significant increases in both ulcer number and ulcer severity; while the females though showed a trend towards increase in both the parameters, the extent of changes was far less than in males.

--- ABSTRACT ---

PMID:23782143 DOI:10.1111/jpc.12302

2015 Current pharmaceutical design

* Gender Based Differences in Stress-induced Gastric Ulcer Formation and its Regulation by Nitric Oxide (NO): An Experimental Study.

- A variety of physiological and pharmacological factors are known to influence stress responses. Cold restraint stress (CRS) induced gastric ulcerogenesis in both the sexes but such ulceration was found to be markedly higher in male than in female rats. In males, CRS induced significant increases in both ulcer number and ulcer severity; while the females though showed a trend towards increase in both the parameters, the extent of changes was far less than in males. Pre-administration of the NO mimetic, L-Arginine (500 and 1000 mg/kg), prior to CRS, dose dependently decreased ulcer number and severity in male rats. In female rats, L-Arginine also induced a gastric cytoprotective effect during CRS but to a much lesser extent. On the other hand, inhibition of NO synthesis by LNAME (25 and 50 mg/kg) further aggravated such stress ulcerogensis in both males and females, with aggravations being more extensive in males. CRS induced ulcerogenesis was associated with reductions in levels of brain and plasma NOx and GSH levels while MDA levels were elevated in both male and female rats- the magnitude of these changes being higher in males than in females. In female rats, pretreatment with formestane (aromatase inhibitor) but not tamoxifen (estrogen receptor blocker) aggravated stress ulcer formation as compared to vehicle treated CRS exposed rats. Formestane pretreatment also induced greater suppressions in brain NOx and GSH and elevations in brain MDA, as compared to vehicle treated CRS rats. These results indicate that estrogen and its interactions with oxidative stress markers and NO plays a key role in the gender based differences in stress induced gastric ulcerogenesis. It may be speculated that, in males, CRS induces greater reductions in brain NO and enhancement in oxidative injury resulting in greater severity of gastric ulceration. On the other hand, greater resistance of females to ulcerogenic effects of CRS may be due to the protection conferred by estrogen and this effect seems to be related to interactions with brain NO.

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(1)420 of	(4)4 null	(7)2 as	(10)2 needed
(2)13 and	(5)3 line	(8)2 however,
(3)7 in	(6)3 than	(9)2 increased

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--- WordNet output for number --- =>に番号をつける, 数, 番号, 総数, 若干, 多数, 曲, 過ごす, 達する, 番号を唱える Overview of noun number The noun number has 11 senses (first 9 from tagged texts) 1. (131) number, figure -- (the property possessed by a sum or total or indefinite quantity of units or individuals; "he had a number of chores to do"; "the number of parameters is small"; "the figure was about a thousand") 2. (63) number -- (a concept of quantity involving zero and units; "every number has a unique position in the sequence") 3. (5) act, routine, number, turn, bit -- (a short theatrical performance that is part of a longer program; "he did his act three times every evening"; "she had a catchy little routine"; "it was one of the best numbers he ever did") 4. (5) phone number, telephone number, number -- (the number is used in calling a particular telephone; "he has an unlisted number") 5. (2) numeral, number -- (a symbol used to represent a number; "he learned to write the numerals before he went to school") 6. (2) issue, number -- (one of a series published periodically; "she found an old issue of the magazine in her dentist's waiting room") 7. (1) number -- (a select company of people; "I hope to become one of their number before I die") 8. (1) number, identification number -- (a numeral or string of numerals that is used for identification; "she refused to give them her Social Security number") 9. (1) number -- (a clothing measurement; "a number 13 shoe") 10. number -- (the grammatical category for the forms of nouns and pronouns and verbs that are used depending on the number of entities involved (singular or dual or plural); "in English the subject and the verb must agree in number") 11. number -- (an item of merchandise offered for sale; "she preferred the black nylon number"; "this sweater is an all-wool number") Overview of verb number The verb number has 6 senses (first 3 from tagged texts) 1. (6) total, number, add up, come, amount -- (add up in number or quantity; "The bills amounted to $2,000"; "The bill came to $2,000") 2. (2) number -- (give numbers to; "You should number the pages of the thesis") 3. (1) number, list -- (enumerate; "We must number the names of the great mathematicians") 4. count, number -- (put into a group; "The academy counts several Nobel Prize winners among its members") 5. count, number, enumerate, numerate -- (determine the number or amount of; "Can you count the books on your shelf?"; "Count your change") 6. number, keep down -- (place a limit on the number of) --- WordNet end ---