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392826 occurrences (No.45 in the rank) during 5 years in the PubMed. [no cache] 500 found
1) Significant (P < 0.05) induction of the intracellular ROS content (%) was observed in 1 mg/L of β-NF exposed T.
--- ABSTRACT ---
PMID:24136887 DOI:10.1002/tox.21911
2015 Environmental toxicology
* β-Naphthoflavone induces oxidative stress in the intertidal copepod, Tigriopus japonicus.
- β-Naphtoflavone (β-NF) is a flavonoid and enhances oxidative stress in vertebrates with little information from aquatic invertebrates as yet. In this study, we investigated the effects of β-NF on the antioxidant defense systems of the intertidal copepod Tigriopus japonicus. To measure the β-NF-triggered changes in oxidative stress markers, such as intracellular reactive oxygen species (ROS), glutathione (GSH) concentration, residual glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR), and superoxide dismutase (SOD) activity, T. japonicus were exposed to β-NF (0.5 and 1 mg/L) for 72 h. Significant (P < 0.05) induction of the intracellular ROS content (%) was observed in 1 mg/L of β-NF exposed T. japonicus, compared to the negative control and H2O2-exposed group. The GSH levels were significantly increased in the 0.5 mg/L of β-NF-exposed group for 12 h and 1 mg/L of β-NF-exposed groups for 12-24 h. GPx, GST, and GR activities showed a significant increase in the 1 mg/L β-NF-exposed group, indicating that β-NF induces oxidative stress in T. japonicus. To understand the effects of β-NF at the level of transcript expression, a 6K microarray analysis was employed. Transcript profiles of selected antioxidant-related genes were modulated after 72 h exposure to 1 mg/L of β-NF. From microarray data, 10 GST isoforms, GR, GPx, PH-GPx, and Se-GPx were chosen for a time-course test by real-time RT-PCR. T. japonicus GST-S, GST-O, GST-M, and GST-D1 were significantly increased in a 1 mg/L β-NF-exposed group. T. japonicus GPx, GR, and Se-GPx mRNA levels were also significantly increased at both concentrations. Our results revealed that oxidative stress was induced by β-NF exposure in T. japonicus.
--- ABSTRACT END ---
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--- WordNet output for observed --- Overview of verb observe The verb observe has 9 senses (first 8 from tagged texts) 1. (39) detect, observe, find, discover, notice -- (discover or determine the existence, presence, or fact of; "She detected high levels of lead in her drinking water"; "We found traces of lead in the paint") 2. (17) note, observe, mention, remark -- (make mention of; "She observed that his presentation took up too much time"; "They noted that it was a fine day to go sailing") 3. (12) note, take note, observe -- (observe with care or pay close attention to; "Take note of this chemical reaction") 4. (10) observe -- (watch attentively; "Please observe the reaction of these two chemicals") 5. (4) respect, honor, honour, abide by, observe -- (show respect towards; "honor your parents!") 6. (3) observe, celebrate, keep -- (behave as expected during of holidays or rites; "Keep the commandments"; "celebrate Christmas"; "Observe Yom Kippur") 7. (2) watch, observe, follow, watch over, keep an eye on -- (follow with the eyes or the mind; "Keep an eye on the baby, please!"; "The world is watching Sarajevo"; "She followed the men with the binoculars") 8. (1) observe, keep, maintain -- (stick to correctly or closely; "The pianist kept time with the metronome"; "keep count"; "I cannot keep track of all my employees") 9. observe, keep -- (conform one's action or practice to; "keep appointments"; "she never keeps her promises"; "We kept to the original conditions of the contract") Overview of adj observed The adj observed has 1 sense (first 1 from tagged texts) 1. (7) ascertained, discovered, observed -- (discovered or determined by scientific observation; "variation in the ascertained flux depends on a number of factors"; "the discovered behavior norms"; "discovered differences in achievement"; "no explanation for the observed phenomena") --- WordNet end ---