kwic
observed
observed
right
off
ON
401
1
100
500
strict
ELIZA cgi-bash version rev. 1.91
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
return
kwic search for observed out of >500 occurrences
392826 occurrences (No.45 in the rank) during 5 years in the PubMed. [cache]
--- ABSTRACT ---
--- ABSTRACT END ---
[frequency of next (right) word to observed]
392826 occurrences (No.45 in the rank) during 5 years in the PubMed. [cache]
| 401) We observed accumulation of nuclear debris in the lungs of neutropenic mice exposed to acid-induced injury compared with wild type. |
| PMID:32959045 DOI:10.1182/blood.2020005505 |
| 2021 Blood |
| * Neutrophils promote clearance of nuclear debris following acid-induced lung injury. |
| - Neutrophils are critical mediators of host defense in pathogen-induced and sterile inflammation. Excessive neutrophil activation has been associated with increased host pathology through collateral organ damage. The beneficial aspects of neutrophil activation, particularly in sterile inflammation, are less well defined. We observed accumulation of nuclear debris in the lungs of neutropenic mice exposed to acid-induced injury compared with wild type. Size analysis of DNA debris showed that neutropenic mice were unable to degrade extracellular DNA fragments. In addition, we found that neutrophils are able to differentially express DNA-degrading and repair-associated genes and proteins. Once neutrophils are at sites of lung inflammation, they are able to phagocytose and degrade extracellular DNA. This neutrophil-dependent DNA degradation occurs in a MyD88-dependent pathway. The increased DNA debris in neutropenic mice was associated with dysregulated alveolar repair and the phenotype is rescued by intratracheal administration of DNase I. Thus, we show a novel mechanism as part of the inflammatory response, in which neutrophils engulf and degrade extracellular DNA fragments and allow for optimal organ repair. |
[
right
kwic]
(1)119  in |
(11)6 a |
(21)4 when |
(31)2 associations |
| (2)35 *null* | (12)6 an |
(22)3 among |
(32)2 differences |
| (3)35 for |
(13)6 the |
(23)3 data |
(33)2 due |
| (4)23 that |
(14)5 as |
(24)3 enhanced |
(34)2 enzyme |
| (5)23 with |
(15)5 at |
(25)3 increased |
(35)2 increase |
| (6)18 between |
(16)4 on |
(26)3 interim |
(36)2 reading |
| (7)10 by |
(17)4 only |
(27)3 previously |
(37)2 significant |
| (8)9 and |
(18)4 to |
(28)3 significantly |
|
| (9)9 during |
(19)4 under |
(29)2 (p |
|
| (10)7 after |
(20)4 using |
(30)2 THC |
add keyword
--- WordNet output for observed ---